{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T16:40:32Z","timestamp":1740156032342,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T00:00:00Z","timestamp":1603843200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key R&D Program of China","award":["2016YFC0104700","31600758","81471735","61427806","7174287","Z181100006218099","BHTR-KFJJ-202001"],"award-info":[{"award-number":["2016YFC0104700","31600758","81471735","61427806","7174287","Z181100006218099","BHTR-KFJJ-202001"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2016YFC0104700","31600758","81471735","61427806","7174287","Z181100006218099","BHTR-KFJJ-202001"],"award-info":[{"award-number":["2016YFC0104700","31600758","81471735","61427806","7174287","Z181100006218099","BHTR-KFJJ-202001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005089","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["2016YFC0104700","31600758","81471735","61427806","7174287","Z181100006218099","BHTR-KFJJ-202001"],"award-info":[{"award-number":["2016YFC0104700","31600758","81471735","61427806","7174287","Z181100006218099","BHTR-KFJJ-202001"]}],"id":[{"id":"10.13039\/501100005089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["2016YFC0104700","31600758","81471735","61427806","7174287","Z181100006218099","BHTR-KFJJ-202001"],"award-info":[{"award-number":["2016YFC0104700","31600758","81471735","61427806","7174287","Z181100006218099","BHTR-KFJJ-202001"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beihang University & Capital Medical University","award":["2016YFC0104700","31600758","81471735","61427806","7174287","Z181100006218099","BHTR-KFJJ-202001"],"award-info":[{"award-number":["2016YFC0104700","31600758","81471735","61427806","7174287","Z181100006218099","BHTR-KFJJ-202001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,10,28]]},"abstract":"<jats:p>Purpose. Considering that intraocular pressure (IOP) is an important confounding factor in corneal biomechanical evaluation, the notion of matching IOP should be introduced to eliminate any potential bias. This study aimed to assess the capability of a novel parameter set (NPS) derived from IOP-matched scenario to diagnose keratoconus. Methods. Seventy samples (training set; 35 keratoconus and 35 normal corneas; pairwise matching for IOP) were used to determine NPS by forward logistic regression. A large validation dataset comprising 62 matching samples (31 keratoconus and 31 normal corneas) and 203 unmatching samples (112 keratoconus and 91 normal corneas) was used to evaluate its clinical significance. To further assess its diagnosis capability, NPS was compared with the other two prior biomechanical indexes. Results. NPS was comprised of three biomechanical parameters, namely, DA Ratio Max 1\u2009mm (DRM1), the first applanation time (AT1), and an energy loading parameter (Eload). NPS was successfully applied to the validation dataset, with a higher accuracy of 96.8% and 95.6% in the IOP-matched and -unmatched scenarios, respectively. More surprisingly, accuracy of NPS was 95.5% in the combined validation, an improvement compared to the two prior biomechanical indexes. Conclusions. This is the first study taking IOP bias into consideration to determine a biomechanical parameter set. Our study shows that NPS indeed offers comparable performance in keratoconus diagnosis. Translational Relevance. Determining a parameter set after eliminating the influence from IOP is useful in revealing the essential differences between keratoconus and normal corneas and possibly facilitating further progress in keratoconus diagnosis.<\/jats:p>","DOI":"10.1155\/2020\/6530279","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:20:05Z","timestamp":1603930805000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Keratoconus Diagnosis: Validation of a Novel Parameter Set Derived from IOP-Matched Scenario"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8064-5666","authenticated-orcid":true,"given":"Dan","family":"Lin","sequence":"first","affiliation":[{"name":"Shenzhen University, Health Science Center, School of Biomedical Engineering, Xueyuan Avenue 1066, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7216-5352","authenticated-orcid":true,"given":"Lei","family":"Tian","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Ophthalmology & Visual Sciences Key Laboratory, National Engineering Research Center for Ophthalmology, Beijing 100730, China"},{"name":"Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beihang University and Capital Medical University, Beijing Tongren Hospital, Beijing 100730, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2253-0526","authenticated-orcid":true,"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen University, Health Science Center, School of Biomedical Engineering, Xueyuan Avenue 1066, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6596-1844","authenticated-orcid":true,"given":"Like","family":"Wang","sequence":"additional","affiliation":[{"name":"Shenzhen University, Health Science Center, School of Biomedical Engineering, Xueyuan Avenue 1066, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2649-8241","authenticated-orcid":true,"given":"Ying","family":"Jie","sequence":"additional","affiliation":[{"name":"Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0067-8466","authenticated-orcid":true,"given":"Yongjin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shenzhen University, Health Science Center, School of Biomedical Engineering, Xueyuan Avenue 1066, Shenzhen 518055, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12211"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.06.025"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2006.103408"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000184"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201500245"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/opx.0b013e318279eb87"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3928\/1081597x-20160524-01"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2013.12.024"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3928\/1081597x-20140930-01"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.3928\/1081597x-20160629-01"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.3928\/1081597x-20170807-02"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3928\/1081597x-20170621-03"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2008.02.020"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2010.12.049"},{"issue":"13","key":"15","first-page":"2537","article-title":"Baseline findings in the collaborative longitudinal evaluation of keratoconus (CLEK) study","volume":"39","author":"K. 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