{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:12:29Z","timestamp":1788437549823,"version":"build-2803163510"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":350,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shenzhen Science and Technology Research Program","award":["JCYJ20170412174037594"],"award-info":[{"award-number":["JCYJ20170412174037594"]}]},{"name":"Shenzhen Science and Technology Research Program","award":["JCYJ20170307155203481"],"award-info":[{"award-number":["JCYJ20170307155203481"]}]},{"name":"Shenzhen Science and Technology Research Program","award":["SZSM201612001"],"award-info":[{"award-number":["SZSM201612001"]}]},{"DOI":"10.13039\/501100012151","name":"San Ming Project of Medicine in Shenzhen","doi-asserted-by":"crossref","award":["JCYJ20170412174037594"],"award-info":[{"award-number":["JCYJ20170412174037594"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012151","name":"San Ming Project of Medicine in Shenzhen","doi-asserted-by":"crossref","award":["JCYJ20170307155203481"],"award-info":[{"award-number":["JCYJ20170307155203481"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012151","name":"San Ming Project of Medicine in Shenzhen","doi-asserted-by":"crossref","award":["SZSM201612001"],"award-info":[{"award-number":["SZSM201612001"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>To determine if the effect of manipulative acupuncture monitored by laser speckle contrast imaging (LSCI) can improve facial blood perfusion in patients with severe Bell\u2019s palsy. This randomized, single\u2010blind, controlled trial included 120 newly diagnosed patients (within 14 days) with severe Bell\u2019s palsy (House\u2013Brackmann grading system (HBGS)\u2009\u2265\u2009grade IV). The patients were randomized (1\u2009:\u20091) to receive either acupoints acupuncture combined with manipulations of twirling, lifting, and thrusting treatments (manipulative acupuncture) or acupoints acupuncture therapy alone (simple acupuncture). These treatments consisted of a total of 24 sessions, three times per week, and each treatment lasted for 30\u2009min. Following 8 weeks of treatment and 6 months after the initial onset of facial palsy, facial nerve functioning was scored (HBGS) and clinical efficacy was measured. The patients\u2019 facial blood perfusion significantly improved following manipulative acupuncture assisted by LSCI compared with that at baseline (<jats:italic>P<\/jats:italic> &lt; 0.01). At the conclusion of the 8\u2010week treatment, both groups showed improvement; however, the recovery rate was significantly different (manipulative acupuncture 53.3% vs. simple acupuncture 33.9%, <jats:italic>P<\/jats:italic> &lt; 0.05). Follow\u2010up analysis at 6 months after the onset of facial palsy revealed a significantly higher recovery rate (91.7% vs. 78.0%; <jats:italic>P<\/jats:italic> &lt; 0.05). In addition, the number of treatments in the observation group was less than that in the simple acupuncture therapy group (<jats:italic>P<\/jats:italic> &lt; 0.05). Compared with simple acupuncture therapy, manipulative acupuncture therapy led to a more significant recovery rate in the treatment of severe Bell\u2019s palsy and required a shorter course of treatment. This trial was registered with <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/ChiCTR1800019463\">ChiCTR1800019463<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2020\/6531743","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T02:24:26Z","timestamp":1608171866000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Efficacy of Manipulative Acupuncture Therapy Monitored by LSCI Technology in Patients with Severe Bell\u2019s Palsy: A Randomized Controlled Trial"],"prefix":"10.1155","volume":"2020","author":[{"given":"Weizheng","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhuang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Gou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8437-7611","authenticated-orcid":false,"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0030-6665(20)31118-x"},{"key":"e_1_2_9_2_2","first-page":"107","article-title":"The natural history of bell\u2019s palsy","volume":"4","author":"Peitersen E.","year":"1982","journal-title":"The American Journal of Otology"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1308\/rcsann.2010.92.2.178a"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/003591575104400711"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejme078188"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.3233\/ch-152006"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11726-014-0765-y"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813493390a16"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1364\/boe.4.002269"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1117\/12.231359"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000150700.46377.96"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2020\/6531743.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2020\/6531743.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/6531743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T07:05:20Z","timestamp":1723014320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/6531743"}},"subtitle":[],"editor":[{"given":"Gioacchino","family":"Calapai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/6531743"],"URL":"https:\/\/doi.org\/10.1155\/2020\/6531743","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"value":"1741-427X","type":"print"},{"value":"1741-4288","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-06-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6531743"}}