{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:57:57Z","timestamp":1776895077658,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2020,11,27]]},"abstract":"<jats:p>Patients who undergo chimeric antigen receptor T-cell therapy (CAR T-cell therapy) are immunosuppressed due to multiple factors. While adenovirus and BK virus are well-known pathogens in the context of hematopoietic stem cell transplant, there are no detailed reports of these infections in the setting of CAR T-cell therapy. We describe a 70-year-old male who recently underwent CAR T-cell therapy for diffuse large B-cell lymphoma. He presented with intractable gross hematuria and dysuria. Workup revealed adenovirus viremia and viruria and BK virus viruria. He was treated for adenovirus hemorrhagic cystitis with intravenous cidofovir 1\u2009mg\/kg\/day, every three days for three weeks, with good clinical response. We also discuss the mechanisms of immunosuppression in CAR T-cell therapy as well as the principles of treatment of adenovirus and BK virus infections in the immunosuppressed patient.<\/jats:p>","DOI":"10.1155\/2020\/6621967","type":"journal-article","created":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T13:35:08Z","timestamp":1606484108000},"page":"1-4","source":"Crossref","is-referenced-by-count":9,"title":["Hemorrhagic Cystitis Secondary to Adenovirus and BK Virus Infection in a Diffuse Large B-Cell Lymphoma Patient with Recent CAR T-Cell Therapy"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0724-0766","authenticated-orcid":true,"given":"Abdul Moiz","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Albany Medical Center, Albany, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3792-8975","authenticated-orcid":true,"given":"Zainub","family":"Ajmal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Albany Medical Center, Albany, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5989-1117","authenticated-orcid":true,"given":"Fatima","family":"Tuz Zahra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Albany Medical Center, Albany, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ananthakrishnan","family":"Ramani","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Albany Medical Center, Albany, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ira","family":"Zackon","sequence":"additional","affiliation":[{"name":"New York Oncology Hematology, Albany Medical Center, Albany, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-1591.65380"},{"issue":"3","key":"2","first-page":"199","article-title":"Mechanisms of hemorrhagic cystitis","volume":"2","author":"S. 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