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Cilnidipine, an L\u2010\/N\u2010type calcium channel blocker (CCB), has unique organ\u2010protective properties due to suppression of hyperactivity in the sympathetic nervous system and renin\u2010angiotensin system (RAS). In this study, we hypothesized that cilnidipine might exert a renoprotective effect by suppressing the RAS.\n                    <jats:italic>Methods<\/jats:italic>\n                    . A total of 25 hypertensive patients receiving a RAS inhibitor were randomly assigned to a cilnidipine (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200912) or amlodipine (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200913) group. The effects of cilnidipine on proteinuria and angiotensin II\u2013renin feedback were assessed.\n                    <jats:italic>Results<\/jats:italic>\n                    . After 6 months of treatment, both systolic and diastolic blood pressures were significantly reduced to a similar extent in both groups. The urine albumin\u2010to\u2010creatinine ratio was significantly lower in the cilnidipine group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05) than in the amlodipine group. Amlodipine increased plasma angiotensin I and angiotensin II levels (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05), whereas cilnidipine did not. Interestingly, the cilnidipine group had a higher ratio of angiotensin\u2010(1\u20137) (Ang\u2010(1\u20137)) to angiotensin II in plasma than the amlodipine group (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05).\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . The L\u2010\/N\u2010type CCB cilnidipine, but not amlodipine, decreased urinary albumin excretion in hypertensive patients. Cilnidipine also increased the ratio of Ang\u2010(1\u20137) to angiotensin II in plasma, which might be one factor underlying its beneficial effects.\n                  <\/jats:p>","DOI":"10.1155\/2020\/6653851","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T16:05:11Z","timestamp":1608653111000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of L\u2010\/N\u2010Type Calcium Channel Blockers on Angiotensin II\u2013Renin Feedback in Hypertensive 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