{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:03:37Z","timestamp":1740171817275,"version":"3.37.3"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals","doi-asserted-by":"publisher","award":["SML20150501","D161100003816005","2016YFC1301800"],"award-info":[{"award-number":["SML20150501","D161100003816005","2016YFC1301800"]}],"id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Beijing Science and Technology Supporting Plan","award":["SML20150501","D161100003816005","2016YFC1301800"],"award-info":[{"award-number":["SML20150501","D161100003816005","2016YFC1301800"]}]},{"name":"National Key Technologies Research and Development Program of China","award":["SML20150501","D161100003816005","2016YFC1301800"],"award-info":[{"award-number":["SML20150501","D161100003816005","2016YFC1301800"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2020,11,30]]},"abstract":"<jats:p>Objective. We aimed to investigate the serum homocysteine (Hcy) level in patients with brain arteriovenous malformation (bAVM) and their impact on neurological outcome during hospitalization. Method. We retrospectively reviewed patients diagnosed with bAVMs in Beijing Tiantan Hospital from January 2019 to August 2020. Patients were divided into two groups according to the mRS (modified Rankin Scale) score at discharge. Clinical and laboratory characteristics were compared. Logistic regression analyses were performed to identify the potential risk factors for short-term neurological outcome. Results. A total of 175 bAVM patients were enrolled in the study, including 139 patients with favorable outcome (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mtext>mRS<\/a:mtext>\n                        <a:mo>\u2264<\/a:mo>\n                        <a:mn>2<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) and 36 patients with unfavorable outcome (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>mRS<\/c:mtext>\n                        <c:mo>&gt;<\/c:mo>\n                        <c:mn>2<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Hyperhomocysteinemia was identified in 32.6% of cases (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>n<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>57<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). Serum Hcy level was related to seizure manifestation (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.034<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>) and short-term neurological outcome (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.027<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). Logistic regression analysis showed that serum glucose (OR 1.897, 95% CI 1.115-3.229; <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.018<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>) and Hcy level (OR 0.838, 95% CI 0.720-0.976; <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>P<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.023<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>) were significantly associated with short-term disability. Conclusion. Our results indicated that the lower serum Hcy level is strongly associated with in-hospital unfavorable outcome. Further prospective studies of Hcy natural history and managements in bAVMs are required, which would be valuable for evaluating the disease-modifying efficacy of oral nutritional supplements in bAVM patients.<\/jats:p>","DOI":"10.1155\/2020\/6661475","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T19:50:14Z","timestamp":1606765814000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Significance of Homocysteine Level on Neurological Outcome in Brain Arteriovenous Malformations"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8705-2652","authenticated-orcid":true,"given":"Fa","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Rd West, Fengtai District, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100070, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4047-0256","authenticated-orcid":true,"given":"Chaofan","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Rd West, Fengtai District, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100070, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5963-9680","authenticated-orcid":true,"given":"Peicong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Rd West, Fengtai District, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100070, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Rd West, Fengtai District, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100070, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4919-5390","authenticated-orcid":true,"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Rd West, Fengtai District, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100070, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7304-0255","authenticated-orcid":true,"given":"Jizong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring Rd West, Fengtai District, Beijing 100070, China"},{"name":"China National Clinical Research Center for Neurological Diseases, Beijing 100070, China"},{"name":"Center of Stroke, Beijing Institute for Brain Disorders, Beijing 100070, China"},{"name":"Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing 100070, China"},{"name":"Savaid Medical School, University of the Chinese Academy of Sciences, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1056\/NEJMcp067192"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.1056\/NEJMoa1709449"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1016\/s0140-6736(11)60872-6"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1001\/jama.300.7.795"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1161\/01.str.0000086753.00555.0d"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1038\/s41598-018-21019-3"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1007\/s10103-018-2485-x"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1016\/j.wneu.2016.09.080"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.1161\/strokeaha.109.558403"},{"doi-asserted-by":"publisher","key":"10","DOI":"10.1161\/01.str.0000061888.71524.df"},{"doi-asserted-by":"publisher","key":"11","DOI":"10.1186\/s13041-015-0116-z"},{"doi-asserted-by":"publisher","key":"12","DOI":"10.1161\/STROKEAHA.119.025033"},{"doi-asserted-by":"publisher","key":"13","DOI":"10.1002\/jcp.21757"},{"doi-asserted-by":"publisher","key":"14","DOI":"10.1155\/2011\/783721"},{"doi-asserted-by":"publisher","key":"15","DOI":"10.1007\/s10143-019-01138-9"},{"doi-asserted-by":"publisher","key":"16","DOI":"10.1161\/01.cir.103.21.2644"},{"doi-asserted-by":"publisher","key":"17","DOI":"10.3171\/jns.1986.65.4.0476"},{"doi-asserted-by":"publisher","key":"18","DOI":"10.1227\/01.neu.0000367555.16733.e1"},{"doi-asserted-by":"publisher","key":"19","DOI":"10.3171\/2016.10.jns161415"},{"doi-asserted-by":"publisher","key":"20","DOI":"10.1161\/strokeaha.108.533216"},{"doi-asserted-by":"publisher","key":"21","DOI":"10.1186\/s12929-020-00655-w"},{"doi-asserted-by":"publisher","key":"22","DOI":"10.1016\/j.brainresbull.2018.05.007"},{"doi-asserted-by":"publisher","key":"23","DOI":"10.1161\/01.str.0000069017.78624.37"},{"doi-asserted-by":"publisher","key":"24","DOI":"10.1161\/01.cir.0000131942.77635.2d"},{"doi-asserted-by":"publisher","key":"25","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.11.005"},{"doi-asserted-by":"publisher","key":"26","DOI":"10.1016\/j.wneu.2019.03.024"},{"doi-asserted-by":"publisher","key":"27","DOI":"10.1212\/wnl.0000000000009093"},{"doi-asserted-by":"publisher","key":"28","DOI":"10.1007\/s007260170009"},{"doi-asserted-by":"publisher","key":"29","DOI":"10.3171\/2011.2.jns101414"},{"doi-asserted-by":"publisher","key":"30","DOI":"10.3171\/2017.2.jns162933"},{"doi-asserted-by":"publisher","key":"31","DOI":"10.1007\/s11011-018-0268-5"},{"doi-asserted-by":"publisher","key":"32","DOI":"10.1007\/s00701-014-2297-0"},{"doi-asserted-by":"publisher","key":"33","DOI":"10.1161\/strokeaha.120.030027"},{"doi-asserted-by":"publisher","key":"34","DOI":"10.1016\/s0140-6736(07)60854-x"},{"doi-asserted-by":"publisher","key":"35","DOI":"10.1161\/strokeaha.115.011258"},{"doi-asserted-by":"publisher","key":"36","DOI":"10.1007\/s00134-008-1044-5"},{"doi-asserted-by":"publisher","key":"37","DOI":"10.1200\/jco.1998.16.1.393"},{"doi-asserted-by":"publisher","key":"38","DOI":"10.1186\/s13023-020-01485-7"},{"doi-asserted-by":"publisher","key":"39","DOI":"10.1200\/jco.2003.07.056"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2020\/6661475.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2020\/6661475.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2020\/6661475.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T19:50:21Z","timestamp":1606765821000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2020\/6661475\/"}},"subtitle":[],"editor":[{"given":"Wen-Jun","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,30]]},"references-count":39,"alternative-id":["6661475","6661475"],"URL":"https:\/\/doi.org\/10.1155\/2020\/6661475","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"type":"electronic","value":"1875-8630"},{"type":"print","value":"0278-0240"}],"subject":[],"published":{"date-parts":[[2020,11,30]]}}}