{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:07:37Z","timestamp":1788887257880,"version":"build-2803163510"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T00:00:00Z","timestamp":1606867200000},"content-version":"vor","delay-in-days":336,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009698","name":"Hawassa University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009698","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . Over the past decade, drug resistance pattern has worsened for many of the uropathogens due to overuse of antibiotics for empiric treatment. The burden of extended spectrum beta\u2010lactamase (ESBL) producing\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    associated urinary tract infections (UTI) has become increasingly more common, limiting treatment options among children presenting with febrile UTI. We investigated the burden and correlates of ESBL producing\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    associated UTI among children and antibacterial resistance pattern.\n                    <jats:italic>Methods<\/jats:italic>\n                    . 284 midstream urine specimens were collected using standard aseptic techniques from 284 children who were diagnosed with suspected UTI. Urine culture and bacteria isolation were performed following standard bacteriological techniques. The Kirby\u2010Bauer disk diffusion technique and the double\u2010disc synergy test were used to investigate antibiotic susceptibility and presence of ESBL production.\n                    <jats:italic>Results<\/jats:italic>\n                    . UTI was confirmed using a positive urine culture for a relevant pathogen in 96\/284 (33.8%) of the cases.\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    accounted for 75% (72\/96) of etiologies of UTI in children. The most frequent\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    spp. were\n                    <jats:italic>E. coli<\/jats:italic>\n                    , 44.4% (32\/72) and\n                    <jats:italic>K. pneumonia<\/jats:italic>\n                    , 27.8% (20\/72). The overall multidrug resistance rate was 86.1% (62\/72). ESBL\u2010producers accounted for 41.7% (30\/72) of the isolated\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    . ESBL producing\n                    <jats:italic>K. pneumonia<\/jats:italic>\n                    and\n                    <jats:italic>E. coli<\/jats:italic>\n                    isolates accounted for 70% (14\/20) and 37.5% (12\/32), respectively. History of UTI in the past 1 year (adjusted\u2009odds\u2009ratio\u2009(AoR) = 0.08, 95\n                    <jats:italic>%<\/jats:italic>\n                    CI\u2009(0.01 \u2212 0.57)) and medium family wealth index (AoR = 0.03, 95\n                    <jats:italic>%<\/jats:italic>\n                    CI\u2009(0.00 \u2212 0.27)) protected from infection with ESBL\u2010producing\n                    <jats:italic>Enterobacteriaceae. Conclusion<\/jats:italic>\n                    . ESBL production was more common in\n                    <jats:italic>K. pneumonia<\/jats:italic>\n                    and appeared to be a major factor contributing drug resistance UTI in children. The findings call for the need to incorporate ESBL testing in the routine clinical practice. The resistance level to commonly prescribed first\u2010line antibiotics observed within\n                    <jats:italic>Enterobacteriaceae<\/jats:italic>\n                    was alarming calling for strengthened antimicrobial stewardship.\n                  <\/jats:p>","DOI":"10.1155\/2020\/6679029","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T22:21:10Z","timestamp":1606947670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Pediatric Febrile Urinary Tract Infection Caused by ESBL Producing\n                    <i>Enterobacteriaceae<\/i>\n                    Species"],"prefix":"10.1155","volume":"2020","author":[{"given":"Asnakech","family":"Agegnehu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mesfin","family":"Worku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Demiss","family":"Nigussie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birhanu","family":"Lulu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4005-8605","authenticated-orcid":false,"given":"Birkneh Tilahun","family":"Tadesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-015-0054-7"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.21767\/2172-0479.100081"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2016.06.009"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-6-487"},{"key":"e_1_2_10_5_2","first-page":"271","article-title":"Risk factors for community acquired urinary tract infection caused by ESBI-producing bacteria","volume":"11","author":"Mahesh E.","year":"2010","journal-title":"Journal, Indian Academy of Clinical Medicine"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40138-013-0021-7"},{"key":"e_1_2_10_7_2","volume-title":"Antibiotic resistance threats in the United States In. U.S. department of health and human services: centers for disease control and prevention","author":"CDC","year":"2013"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363040-00002"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2713-1"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.11-0057"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161685"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S127177"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/CBO9780511543470"},{"key":"e_1_2_10_14_2","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing. In: 27th Edition, CLSI Supplement M100","author":"CLSI","year":"2017"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166519"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.4236\/aim.2016.67054"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.5376\/mmr.2015.04.0001"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-019-0488-4"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.9734\/JAMPS\/2015\/15384"},{"key":"e_1_2_10_20_2","unstructured":"SegarL. KumarS. JosephN. M. andSivaramanU. Prevalence of extended spectrum beta-lactamases among Enterobacteriaceae and their anti-biogram pattern from various clinical samples 2015 8 no. 5 220\u2013223 https:\/\/innovareacademics.in\/journals\/index.php\/ajpcr\/article\/view\/7416."},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1655-3"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.4172\/2576-389X.1000116"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.4172\/2472-4998.1000102"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.afju.2014.10.004"},{"key":"e_1_2_10_25_2","first-page":"161","article-title":"Prevalence of extended-spectrum-\u03b2-lactamase-producing Escherichia coli isolates among uropathogensin a pediatrics hospital","volume":"8","author":"Khaledi A.","year":"2016","journal-title":"Der Pharma Chemica"},{"key":"e_1_2_10_26_2","doi-asserted-by":"crossref","unstructured":"KimaY. H. YangaE. M. andKimaC. J. Urinary tract infection caused by community-acquired extended-spectrum-lactamase-producing bacteria in infants journal of pediatric 2017 93 no. 3 260\u2013266 https:\/\/doi.org\/10.1016\/j.jped.2016.06.009 2-s2.0-85007311822 27842212.","DOI":"10.1016\/j.jped.2016.06.009"},{"key":"e_1_2_10_27_2","first-page":"571","article-title":"Urinary tract infections caused by extended-spectrum beta-lactamase-producing bacteria in children: a matched case-control study","volume":"55","author":"Dotis J.","year":"2013","journal-title":"The Turkish Journal of Pediatrics"},{"key":"e_1_2_10_28_2","article-title":"Bacterial uropathogens in urinary tract infection and antibiotic susceptibility pattern in Jimma University Specialized Hospital, Southwest Ethiopia","volume":"21","author":"Beyene G.","year":"2011","journal-title":"Ethiopian Journal of Health Science"},{"key":"e_1_2_10_29_2","first-page":"101","article-title":"Prevalence of multiple drug resistant clinical isolates of extended-spectrum beta-lactamase producing Enterobacteriaceae in Southeast Iran","volume":"35","author":"Shahla Mansouri S. A.","year":"2010","journal-title":"Iran journal of Medical Sciences"},{"key":"e_1_2_10_30_2","first-page":"741","article-title":"Frequency of extended spectrum beta lactamase producing enterobacteriaceae among urinary pathogen isolates","volume":"21","author":"Afridi F. I.","year":"2011","journal-title":"Journal of the College of Physicians and Surgeons Pakistan"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/258517"},{"key":"e_1_2_10_32_2","article-title":"Prevalence of multidrug resistant Enterobacteriaceae and extended spectrum \u03b2 lactamase producing Escherichia coli in urinary tract infection","volume":"4","author":"Thakur S.","year":"2013","journal-title":"Research Journal of Pharmaceutical, Biological and Chemical Sciences"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2019.002"},{"key":"e_1_2_10_34_2","article-title":"Antimicrobial sensitivity pattern of Escherichia coli causing urinary tract infection in Bangladeshi patients","volume":"4","author":"Akhtar N.","year":"2016","journal-title":"American Journal of Microbiological Research"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/6679029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/6679029.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/6679029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T09:02:40Z","timestamp":1735635760000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/6679029"}},"subtitle":[],"editor":[{"given":"Cem","family":"Karadeniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/6679029"],"URL":"https:\/\/doi.org\/10.1155\/2020\/6679029","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6679029"}}