{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:02:57Z","timestamp":1780444977950,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400428"],"award-info":[{"award-number":["81400428"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701686"],"award-info":[{"award-number":["81701686"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2020,12,18]]},"abstract":"<jats:p>Aim. To identify the guinea pig eyeball with edge detection and curve fitting and devise a noncontact technology of measuring ocular morphological parameters of small experimental animal. Methods. Thirty-nine eyeballs of guinea pig eyeballs were photographed to obtain the anterior and posterior surface; transverse and sagittal planes after the eyeballs were eviscerated. Next, the eyeball photos were input into digital image analysis software; the corresponding photo pixels-actual length ratio was acquired by a proportional scale. The contour lines of the eyeballs were identified by edge detection technology; conic curve fitting was applied to fit the contour line of the eyeball. The maximum and minimum diameters, the horizontal and vertical diameters, eccentricity, tilt angle, cross-sectional area, equatorial circumference, retrobulbar equatorial maximum length, corneal radius of curvature (CRC) in central region, and the whole cornea were calculated according to the geometric principles. The corneal data of in vitro study were compared with the in vivo results. Results. The contour line of the selected guinea pig eye was identified correctly by edge detection. There were no significant differences between anterior and posterior surfaces of one eyeball in the maximum diameters, eccentricity, cross-sectional area, equatorial circumference, and tilt angle (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&gt;<\/a:mo>\n                        <a:mn>0.01<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). There were significant differences of eccentricity and CRC between central region and the whole cornea (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.01<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). There were no significant differences between keratometer in vivo and cornea in vitro. Conclusion. It was feasible to measure an experimental animal eye in a noncontact way. Edge detection and curve fitting technology could accurately evaluate the ocular morphological parameters.<\/jats:p>","DOI":"10.1155\/2020\/6689023","type":"journal-article","created":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T17:05:09Z","timestamp":1608397509000},"page":"1-13","source":"Crossref","is-referenced-by-count":5,"title":["Measuring the Ocular Morphological Parameters of Guinea Pig Eye with Edge Detection and Curve Fitting"],"prefix":"10.1155","volume":"2020","author":[{"given":"Yue","family":"Di","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shanghai Children\u2019s Hospital, Shanghai Jiaotong University, Shanghai 200062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai Children\u2019s Hospital, Shanghai Jiaotong University, Shanghai 200062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-jing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, East Hospital Affiliated to Tongji University, Shanghai 200120, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Tao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Eye & ENT Hospital Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-ting","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai Children\u2019s Hospital, Shanghai Jiaotong University, Shanghai 200062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-yun","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai Children\u2019s Hospital, Shanghai Jiaotong University, Shanghai 200062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-bao","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai Children\u2019s Hospital, Shanghai Jiaotong University, Shanghai 200062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2562-2570","authenticated-orcid":true,"given":"Na","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Huashan Hospital North, Fudan University, Shanghai 200040, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3244-4541","authenticated-orcid":true,"given":"Tong","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Shanghai Children\u2019s Hospital, Shanghai Jiaotong University, Shanghai 200062, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2015.12.004"},{"issue":"9","key":"2","article-title":"IVMED-85 eye drops for myopia control in guinea pigs","volume":"60","author":"S. Molokhia","year":"2019","journal-title":"Investigative Ophthalmology & Visual Science"},{"issue":"8","key":"3","article-title":"Optical aberrations of guinea pig eyes","volume":"58","author":"S. Kochik","year":"2017","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"4","first-page":"666","article-title":"Myopia induced by flickering light in guinea pig eyes is associated with increased rather than decreased dopamine release","volume":"23","author":"X. Luo","year":"2017","journal-title":"Molecular Vision"},{"key":"5","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1186\/1742-9994-12-S1-S13","article-title":"The maternal social environment shapes offspring growth, physiology, and behavioural phenotype in guinea pigs","volume":"12","author":"N. von Engelhardt","year":"2015","journal-title":"Frontiers in Zoology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1186\/s40463-015-0110-6"},{"issue":"4","key":"7","first-page":"9","article-title":"Efficacy of polyprenyl phosphates in the experimental genital herpes model","volume":"60","author":"A. N. Narovlyansky","year":"2015","journal-title":"Voprosy Virusologii"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.03.003"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2006.01.027"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2019.01.004"},{"key":"11","doi-asserted-by":"crossref","article-title":"Detection of syrinx in thermographic images of canines with Chiari malformation using MATLAB CVIP toolbox GUI","author":"A. Karlapalem","DOI":"10.1117\/12.2519112"},{"key":"12","first-page":"743","article-title":"An automated method using MATLAB to identify the adductor sesamoid for determining the onset of puberty and assessing the skeletal age in children","volume-title":"Lecture Notes in Electrical Engineering","author":"K. Prasad","year":"2019"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1007\/s11538-015-0062-z"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2014.10.011"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2008.02103.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2013.09.006"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1186\/s12911-019-1018-2"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.3928\/1081597X-20141218-05"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1039\/C3AN01879B"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1016\/j.visres.2018.09.007"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-679X(03)72012-3"},{"issue":"6","key":"22","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1109\/TPAMI.1986.4767851","article-title":"A computational approach to edge detection","volume":"8","author":"J. Canny","year":"1986","journal-title":"IEEE Transactions on Pattern Analysis and Machine Intelligence"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1038\/476152d"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/572530"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1366\/000370207781745991"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1109\/TUFFC.2013.2704"},{"key":"27","first-page":"117","article-title":"Corneal shape and eccentricity in population","volume":"37","author":"P. Benes","year":"2013","journal-title":"Collegium Antropologicum"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199407000-00009"}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2020\/6689023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2020\/6689023.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2020\/6689023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,19]],"date-time":"2020-12-19T17:05:14Z","timestamp":1608397514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2020\/6689023\/"}},"subtitle":[],"editor":[{"given":"Martti","family":"Juhola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,12,18]]},"references-count":28,"alternative-id":["6689023","6689023"],"URL":"https:\/\/doi.org\/10.1155\/2020\/6689023","relation":{},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12,18]]}}}