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It is typical of many chronic liver diseases, including cirrhosis, and effective drugs are needed. In this study, we explored the protective effect of bergenin on liver fibrosis induced by carbon tetrachloride and bile duct ligation. A variety of molecular biological methods (qRT-PCR, western blotting, and immunohistochemistry) were employed to confirm the increased degree of hepatocyte injury and ECM formation in the disease model, consistent with autophagy and activation of the TGF-\u03b2 pathway. Bergenin activated PPAR-\u03b3 and inhibited TGF-\u03b2 and autophagy and decreased liver fibrosis by inhibiting hepatocyte necrosis and ECM formation in a dose-dependent manner. The results suggest that bergenin may be a promising drug candidate for the treatment of liver fibrosis.<\/jats:p>","DOI":"10.1155\/2020\/6694214","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T19:35:12Z","timestamp":1609443312000},"page":"1-13","source":"Crossref","is-referenced-by-count":28,"title":["Bergenin Attenuates Hepatic Fibrosis by Regulating Autophagy Mediated by the PPAR-\u03b3\/TGF-\u03b2 Pathway"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9425-3612","authenticated-orcid":true,"given":"Yujing","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9638-7964","authenticated-orcid":true,"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4429-9043","authenticated-orcid":true,"given":"Kan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5344-7242","authenticated-orcid":true,"given":"Jiao","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6527-4673","authenticated-orcid":true,"given":"Chuanyong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai 200072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.03.007"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31535"},{"key":"3","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8253831","article-title":"Redox regulation of PPARgamma in polarized macrophages","volume":"2020","author":"V. 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