{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:01:24Z","timestamp":1754485284112,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Gastrointestinal Medicine"],"published-print":{"date-parts":[[2020,1,29]]},"abstract":"<jats:p>Azathioprine is a cornerstone of the therapy of Crohn\u2019s disease. Unfortunately, infections and malignancies are relatively common adverse effects related to this drug; however, cirrhosis is exceptionally reported as a side effect. We report the case of a 49-year-old male patient with ileocolonic steno-penetrating Crohn\u2019s disease who developed hepatic cirrhosis while treated with azathioprine. After taking azathioprine for 3 years with regular follow-up, he developed pancytopenia, and liver cirrhosis was diagnosed with ultrasound, abdomen computed tomography scan, transient elastography, and liver biopsy. As all other causes of liver damage were excluded, azathioprine was believed to be the cause of liver injury and therefore was interrupted.<\/jats:p>","DOI":"10.1155\/2020\/6726384","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T18:31:25Z","timestamp":1580322685000},"page":"1-3","source":"Crossref","is-referenced-by-count":2,"title":["Increased Risk of Liver Cirrhosis during Azathioprine Therapy for Crohn\u2019s Disease"],"prefix":"10.1155","volume":"2020","author":[{"given":"Jenny","family":"Roselli","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences \u201cMario Serio\u201d, University of Florence, Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2154-0490","authenticated-orcid":true,"given":"Tommaso","family":"Innocenti","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Biomedical Sciences 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