{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T21:41:42Z","timestamp":1773351702798,"version":"3.50.1"},"reference-count":88,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Zagreb, Zagreb, Croatia","award":["BM 099"],"award-info":[{"award-number":["BM 099"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Emergency Medicine International"],"published-print":{"date-parts":[[2020,5,27]]},"abstract":"<jats:p>Recently, the pentadecapeptide BPC 157-induced counteraction of bupivacaine cardiotoxicity has been reported. Medication includes (i) lidocaine-induced local anesthesia via intraplantar application and axillary and spinal (L4-L5) intrathecal block, (ii) lidocaine-induced arrhythmias, (iii) convulsions, and (iv) lidocaine-induced HEK293 cell depolarisation. BPC 157 applications (intraplantar, intraperitoneal, and intragastric) were given (i) immediately after lidocaine, (ii) 10\u2009min after, or (iii) 5\u2009min before. The BPC 157\/NO-system relationship was verified with NO-agents, the NOS-blocker L-NAME and the NOS-substrate L-arginine, given alone and\/or together, in axillary and spinal intrathecal blocks. BPC 157 applied immediately after lidocaine or 5\u2009min before the application of lidocaine considerably ameliorated plantar presentation. BPC 157 medication considerably counteracted lidocaine-induced limb function failure; L-NAME was counteracted; L-arginine exhibited counteraction when given immediately after lidocaine, but prolongation was seen when given later. Given together, prophylactically or therapeutically, L-NAME and L-arginine (L-NAME\u2009+\u2009L-arginine) counteracted the other\u2019s response. BPC 157 maintained its original response when given together with L-NAME or L-arginine. When BPC 157 was given together with L-NAME and L-arginine, its original response reappeared. BPC 157 antagonised the lidocaine-induced bradycardia and eliminated tonic-clonic convulsions. Also, BPC 157 counteracted the lidocaine-induced depolarisation of HEK293 cells. Thus, BPC 157 has antidote activity in its own right against lidocaine and local anesthetics.<\/jats:p>","DOI":"10.1155\/2020\/6805354","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T23:37:04Z","timestamp":1590622624000},"page":"1-20","source":"Crossref","is-referenced-by-count":23,"title":["In relation to NO-System, Stable Pentadecapeptide BPC 157 Counteracts Lidocaine-Induced Adverse Effects in Rats and Depolarisation In Vitro"],"prefix":"10.1155","volume":"2020","author":[{"given":"Marin","family":"Lozic","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Medical Faculty, University of Zagreb, Salata 11, P.O. Box 916, 10000 Zagreb, Croatia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilije","family":"Stambolija","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Medical Faculty, University of Zagreb, Salata 11, P.O. 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