{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T11:51:50Z","timestamp":1769860310910,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T00:00:00Z","timestamp":1597881600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hepatology"],"published-print":{"date-parts":[[2020,8,20]]},"abstract":"<jats:p>Hemophagocytic lymphohistiocytosis (HLH) is a rare condition characterized by a pathologic immune dysregulation resulting in extreme inflammation. Clinical manifestations are varied but can include severe multiorgan failure and death. HLH has been associated with malignancies, autoimmune diseases, and infections, such as histoplasmosis. Histoplasmosis commonly has subclinical manifestations but can also present in its disseminated form. We present the case of an immunocompromised patient with worsening liver function caused by hepatic histoplasmosis that later triggered HLH with severe multiorgan dysfunction.<\/jats:p>","DOI":"10.1155\/2020\/6901514","type":"journal-article","created":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T23:33:48Z","timestamp":1597966428000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["A Case of Hemophagocytic Lymphohistiocytosis Secondary to Disseminated Histoplasmosis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Ivan","family":"Columbus-Morales","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas","family":"Maahs","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Henry Ford Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanam","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Pathology, Henry Ford Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart C.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Wayne State University, School of Medicine, Detroit, MI, USA"},{"name":"Department of Gastroenterology, Henry Ford Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kedar V.","family":"Inamdar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Henry Ford Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-1846","authenticated-orcid":true,"given":"Humberto C.","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Wayne State University, School of Medicine, Detroit, MI, USA"},{"name":"Department of Gastroenterology, Henry Ford Hospital, Detroit, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.06.009"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2147\/jbm.s46255"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0740-3"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv140"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-016-1945-9"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4169052"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2018.01.001"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-001-0031-6"},{"key":"9","first-page":"218","volume-title":"Hepatic manifestations of systemic disorders","year":"2017"},{"issue":"6","key":"10","first-page":"429","volume":"41","year":"1984","journal-title":"Archives Fran\u00e7aises de P\u00e9diatrie"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.10.009"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqw053"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2013.10.014"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.21039"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7107326"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1086\/521259"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw305"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmcr.2019.12.013"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myx130"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-03-278127"}],"container-title":["Case Reports in Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihep\/2020\/6901514.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihep\/2020\/6901514.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihep\/2020\/6901514.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,20]],"date-time":"2020-08-20T23:33:50Z","timestamp":1597966430000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihep\/2020\/6901514\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,20]]},"references-count":20,"alternative-id":["6901514","6901514"],"URL":"https:\/\/doi.org\/10.1155\/2020\/6901514","relation":{},"ISSN":["2090-6587","2090-6595"],"issn-type":[{"value":"2090-6587","type":"print"},{"value":"2090-6595","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,20]]}}}