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It has been investigated that arranged exercise would effectively regulate bone metabolism. Until now, a number of systems have discovered how exercise could help bone health. Previous studies reported different mechanisms of the effect of exercise on bone health by modulation of bone remodeling. However, the regulation of RANKL\/RANK\/OPG pathway in exercise and physical performance as one of the most important remodeling systems is not considered comprehensive in previous evidence. Therefore, the aim of this review is to clarify exercise influence on bone modeling and remodeling, with a concentration on its role in regulating RANKL\/RANK\/OPG pathway.<\/jats:p>","DOI":"10.1155\/2020\/6910312","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T18:35:38Z","timestamp":1582223738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":297,"title":["RANKL\/RANK\/OPG Pathway: A Mechanism Involved in Exercise\u2010Induced Bone Remodeling"],"prefix":"10.1155","volume":"2020","author":[{"given":"Mohammad","family":"Tobeiha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed H.","family":"Moghadasian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4666-1918","authenticated-orcid":false,"given":"Sadegh","family":"Jafarnejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,20]]},"reference":[{"key":"e_1_2_6_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10121930"},{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar2165"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf01623184"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2019.02.011"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2007.048868"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/421746"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2012.04.076"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.03.018"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.63.s85.2.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.03.008"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-016-9650-y"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.137"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2014(06)12"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1301\/nr.2007.dec.s147-s151"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/08977190412331279890"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m110.176099"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-007-0024-y"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-017-9732-6"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-017-0406-8"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(17)30310-8"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcp1800214"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.130351"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0377-1237(10)80050-4"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/s8756-3282(00)00376-8"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2007.02.003"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/ijcp.12022"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2015.01.004"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158365"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/sms.13443"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2014.08.003"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-012-0119-y"},{"key":"e_1_2_6_32_2","first-page":"223","article-title":"The effects of exercise on bone. 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