{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:37:15Z","timestamp":1747190235720,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2020,3,10]]},"abstract":"<jats:p>Bone mineral metabolism disease, which included persistent hyperparathyroidism, is common after successful kidney transplantation (KT) and is related with negative outcomes in kidney transplant recipients. There is a lack of information about bone mineral metabolism, persistent hyperparathyroidism, and its risk factors in Latin kidney transplant recipients (KTRs). <jats:italic>Material and Methods<\/jats:italic>: A retrospective study was conducted in 74 patients aged 18\u201350 years with evolution of 12 months after KT and estimated glomerular filtration rate (eGFR) &gt;60\u2009ml\/min; biochemical data of bone mineral metabolism before and at 1, 3, 6, and 12 months of KT were registered. <jats:italic>Results.<\/jats:italic> Age was 33 (IQR 27\u201337) years; 54% (<jats:italic>n<\/jats:italic>\u2009=\u200940) were men. Before KT, all patients had hyperparathyroidism, 40% (<jats:italic>n<\/jats:italic>\u2009=\u200930) hypocalcemia, 86% (<jats:italic>n<\/jats:italic>\u2009=\u200964) hyperphosphatemia, and 42% (<jats:italic>n<\/jats:italic>\u2009=\u200931) hyperphosphatasemia. After KT, an increase of calcium and a diminution of PTH, phosphorus, and alkaline phosphatase were corroborated (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). All patients had hypovitaminosis D (deficiency: 91% (<jats:italic>n<\/jats:italic>\u2009=\u200967); insufficiency: 9% (<jats:italic>n<\/jats:italic>\u2009=\u20097)); 40% (<jats:italic>n<\/jats:italic>\u2009=\u200930) had persistent hyperparathyroidism at 12 months. Hyperphosphatasemia before KT (OR\u2009=\u20094.17 (95% CI: 1.21\u201314.44); <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:mrow><\/mml:math>), hyperparathyroidism at 6 months (OR\u2009=\u20091.84 (95% CI; 1.67\u20132.06); <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.02<\/mml:mn><\/mml:mrow><\/mml:math>), hypovitaminosis D at 6 months (OR\u2009=\u20093.94 (95% CI: 1.86\u201317.9); <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>), and hyperphosphatasemia at 6 months (OR\u2009=\u20091.47 (95% CI: 1.07\u20132.86); <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.03<\/mml:mn><\/mml:mrow><\/mml:math>) were risk factors for persistent hyperparathyroidism at 12 months after KT. <jats:italic>Conclusion<\/jats:italic>. Persistent hyperparathyroidism at 6 months, hypovitaminosis D, and hyperphosphatasemia are risk factors for persistent hyperparathyroidism at 1 year of KT in Latin population.<\/jats:p>","DOI":"10.1155\/2020\/6913506","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T19:38:01Z","timestamp":1583869081000},"page":"1-7","source":"Crossref","is-referenced-by-count":2,"title":["Biochemical Characteristics of Bone Mineral Metabolism before and throughout the First Year after Kidney Transplantation, Persistent Hyperparathyroidism, and Risk Factors in a Latin Population"],"prefix":"10.1155","volume":"2020","author":[{"given":"Lourdes","family":"Balc\u00e1zar-Hern\u00e1ndez","sequence":"first","affiliation":[{"name":"Endocrinology Department, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuauht\u00e9moc 330, Colonia Doctores, 06720 M\u00e9xico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-2925","authenticated-orcid":true,"given":"Guadalupe","family":"Vargas-Ortega","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuauht\u00e9moc 330, Colonia Doctores, 06720 M\u00e9xico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6924-2209","authenticated-orcid":true,"given":"Baldomero","family":"Gonz\u00e1lez-Virla","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuauht\u00e9moc 330, Colonia Doctores, 06720 M\u00e9xico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha","family":"Cruz-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Kidney Transplant Unit, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuauht\u00e9moc 330, Colonia Doctores, 06720 M\u00e9xico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Rodr\u00edguez-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Kidney Transplant Unit, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuauht\u00e9moc 330, Colonia Doctores, 06720 M\u00e9xico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"Espinoza-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Kidney Transplant Unit, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuauht\u00e9moc 330, Colonia Doctores, 06720 M\u00e9xico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Cuevas-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Kidney Transplant Unit, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuauht\u00e9moc 330, Colonia Doctores, 06720 M\u00e9xico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5394-9856","authenticated-orcid":true,"given":"Victoria","family":"Mendoza-Zubieta","sequence":"additional","affiliation":[{"name":"Endocrinology Department, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Cuauht\u00e9moc 330, Colonia Doctores, 06720 M\u00e9xico City, 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