{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T21:21:54Z","timestamp":1771881714529,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T00:00:00Z","timestamp":1583452800000},"content-version":"vor","delay-in-days":65,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"TCM Genre Program of Shanghai Health Bureau","award":["ZY (2018-2020)-CCCX-1006"],"award-info":[{"award-number":["ZY (2018-2020)-CCCX-1006"]}]},{"name":"TCM Genre Program of Shanghai Health Bureau","award":["Shxxjcxk201709"],"award-info":[{"award-number":["Shxxjcxk201709"]}]},{"name":"TCM Genre Program of Shanghai Health Bureau","award":["18401970500"],"award-info":[{"award-number":["18401970500"]}]},{"name":"TCM Genre Program of Shanghai Health Bureau","award":["16401970300"],"award-info":[{"award-number":["16401970300"]}]},{"name":"Financing Scheme of Arising Interdisciplinary Subjects of TCM in Shanghai","award":["ZY (2018-2020)-CCCX-1006"],"award-info":[{"award-number":["ZY (2018-2020)-CCCX-1006"]}]},{"name":"Financing Scheme of Arising Interdisciplinary Subjects of TCM in Shanghai","award":["Shxxjcxk201709"],"award-info":[{"award-number":["Shxxjcxk201709"]}]},{"name":"Financing Scheme of Arising Interdisciplinary Subjects of TCM in Shanghai","award":["18401970500"],"award-info":[{"award-number":["18401970500"]}]},{"name":"Financing Scheme of Arising Interdisciplinary Subjects of TCM in Shanghai","award":["16401970300"],"award-info":[{"award-number":["16401970300"]}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["ZY (2018-2020)-CCCX-1006"],"award-info":[{"award-number":["ZY (2018-2020)-CCCX-1006"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["Shxxjcxk201709"],"award-info":[{"award-number":["Shxxjcxk201709"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["18401970500"],"award-info":[{"award-number":["18401970500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["16401970300"],"award-info":[{"award-number":["16401970300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["ZY (2018-2020)-CCCX-1006"],"award-info":[{"award-number":["ZY (2018-2020)-CCCX-1006"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["Shxxjcxk201709"],"award-info":[{"award-number":["Shxxjcxk201709"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["18401970500"],"award-info":[{"award-number":["18401970500"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Municipal Science and Technology Commission","doi-asserted-by":"crossref","award":["16401970300"],"award-info":[{"award-number":["16401970300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Our aim was to assess the efficacy and safety of acupuncture for OSA patients with various severities of the disorder. <jats:italic>Methods<\/jats:italic>. Eight databases including PubMed, Cochrane Library, EMBASE, Web of Science, China National Knowledge Infrastructure (CNKI), Chongqing VIP (CQVIP), Wanfang Data, and Chinese Biomedical Literature Database (CBM) were comprehensively searched till July 2019. Randomized controlled trials (RCTs) testing acupuncture in the treatment of OSA were eligible for inclusion. Studies were selected for inclusion, and data were extracted by two authors independently. The Cochrane Collaboration\u2019s Risk of Bias Assessment Tool and RevMan software (version 5.3) were used to evaluate the quality of studies and conduct statistical analysis. <jats:italic>Results<\/jats:italic>. Nine RCTs with 584 participants were included. The trials covered acupuncture and electropuncture. Acupuncture caused clinically significant reductions in AHI (MD: \u20106.18; 95% CI: \u20109.58 to \u20102.78; <jats:italic>Z<\/jats:italic> = 3.56, <jats:italic>P<\/jats:italic> = 0.0004) as well as in ESS (MD: \u20102.84; 95% CI: \u20104.80 to \u20100.16, <jats:italic>Z<\/jats:italic> = 2.09, <jats:italic>P<\/jats:italic> = 0.04). AHI was reduced more in the subgroup analysis of moderate OSA patients (MD: \u20109.44; 95% CI: \u201012.44 to \u20106.45; <jats:italic>Z<\/jats:italic> = 6.18, <jats:italic>P<\/jats:italic> &lt; 0.00001) and severe OSA patients (MD: \u201010.09; 95% CI: \u201012.47 to \u20107.71; <jats:italic>Z<\/jats:italic> = 8.31, <jats:italic>P<\/jats:italic> &lt; 0.00001). ESS was also reduced more in the subgroup analysis of moderate OSA patients (MD: \u20102.40; 95% CI: \u20103.63 to \u20101.17; <jats:italic>Z<\/jats:italic> = 3.83, <jats:italic>P<\/jats:italic> = 0.0001) and severe OSA patients (MD: \u20104.64; 95% CI: \u20105.35 to \u20103.92; <jats:italic>Z<\/jats:italic> = 12.72, <jats:italic>P<\/jats:italic> &lt; 0.00001). Besides, acupuncture had a beneficial effect on LSaO<jats:sub>2<\/jats:sub> (MD: 5.29; 95% CI: 2.61 to 7.97; <jats:italic>Z<\/jats:italic> = 3.86, <jats:italic>P<\/jats:italic> = 0.0001). The outcome of AHI and LSaO<jats:sub>2<\/jats:sub> yielded consistent results after sensitivity analysis, but the direction of the outcome of ESS was reversed. And the quality of evidence was mainly low to very low. <jats:italic>Conclusions<\/jats:italic>. Acupuncture therapy is effective for OSA patients in reducing AHI and ESS and in improving the LSaO<jats:sub>2<\/jats:sub> of various severities, especially in moderate and severe OSA patients. High\u2010quality trials are urgently needed.<\/jats:p>","DOI":"10.1155\/2020\/6972327","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T23:31:05Z","timestamp":1583537465000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Acupuncture for Obstructive Sleep Apnea (OSA) in Adults: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Liaoyao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijun","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6755-4380","authenticated-orcid":false,"given":"Jian","family":"Pei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,6]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6506"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1816152"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201811-2173LE"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-2004"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30198-5"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.6034"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2018.09.030"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.10.1396"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12824"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1326ST"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2019.04.009"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2006.04.009"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8792167"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2700"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/32.2.150"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_9_18_2","first-page":"79","article-title":"A study on differences of curative effects of acupuncture and nCPAP for treatment of OSAHS","volume":"28","author":"Chen B.","year":"2008","journal-title":"Zhongguo Zhen Jiu"},{"key":"e_1_2_9_19_2","first-page":"879","article-title":"Clinical observation of obstructive sleep apnea hypopnea syndrome treated by consciousness-restoring and orifices-opening acupuncture","volume":"37","author":"Li X. X.","year":"2017","journal-title":"Henan Traditional Chinese Medicine"},{"key":"e_1_2_9_20_2","volume-title":"Acupuncture in the Treatment of Obstructive Sleep Apnea Syndrome Clinical Observation","author":"Pan H. H.","year":"2012"},{"key":"e_1_2_9_21_2","first-page":"1352","article-title":"Curative observation of the electro-acupuncture and nasal continuous positive airway pressure on patients with obstructive sleep apnea hypoventilations","volume":"24","author":"Song Y. J.","year":"2015","journal-title":"Journal of Emergency in Traditional Chinese Medicine"},{"key":"e_1_2_9_22_2","first-page":"289","article-title":"The curative effect observation of slow twisting needle method in treating obstructive sleep apnea hypopnea syndrome","volume":"38","author":"Su S.","year":"2018","journal-title":"Henan Traditional Chinese Medicine"},{"key":"e_1_2_9_23_2","first-page":"1353","article-title":"Efficacy of electroacupuncture for patients with mild obstructive sleep apnea hypopnea syndrome","volume":"39","author":"Xu T.","year":"2017","journal-title":"Zhejiang Medical Journal"},{"key":"e_1_2_9_24_2","first-page":"192","article-title":"Clinical observation on the effect of acupuncture in the treatment of 90 cases with obstructive sleep apnea","volume":"11","author":"Zhang L. X.","year":"2014","journal-title":"China Health Industry"},{"key":"e_1_2_9_25_2","volume-title":"The Clinical Observation and Mechanism Analysis of the Li Qi Qu Tan Acupuncture Therapy for the Qi-Stagnancy with Phlegm-Blocking Type OSAHS","author":"Zhao D.","year":"2015"},{"key":"e_1_2_9_26_2","first-page":"129","article-title":"Treating 30 patients with obstructive sleep apnea hypopnea syndrome by laryngeal three acupoints","volume":"27","author":"Zhang P. L.","year":"2014","journal-title":"Western Journal of Traditional Chinese Medicine"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/aim.2009.001867"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7640"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7638"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/6972327.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2020\/6972327.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/6972327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T11:44:25Z","timestamp":1735645465000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/6972327"}},"subtitle":[],"editor":[{"given":"Francesco","family":"Onida","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/6972327"],"URL":"https:\/\/doi.org\/10.1155\/2020\/6972327","archive":["Portico"],"relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2019-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-26","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6972327"}}