{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:41:31Z","timestamp":1790628091506,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T00:00:00Z","timestamp":1586217600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["NRF-2018R1D1A3B07048683"],"award-info":[{"award-number":["NRF-2018R1D1A3B07048683"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["HI14C2161"],"award-info":[{"award-number":["HI14C2161"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2018R1D1A3B07048683"],"award-info":[{"award-number":["NRF-2018R1D1A3B07048683"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["HI14C2161"],"award-info":[{"award-number":["HI14C2161"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["NRF-2018R1D1A3B07048683"],"award-info":[{"award-number":["NRF-2018R1D1A3B07048683"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C2161"],"award-info":[{"award-number":["HI14C2161"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2020,4,7]]},"abstract":"<jats:p><jats:italic>Background and Purpose<\/jats:italic>. Recently, tonsil-derived mesenchymal stem cells (T-MSCs) have attracted great attention in various medical fields due to easier harvest of T-MSCs and more immunomodulatory effects than adipose-derived MSCs. However, there was still little evidence of the effect of conditioned media from T-MSCs (T-MSCs-CM) on allergic rhinitis (AR). Therefore, we investigated the impact of T-MSCs-CM on an AR mouse model. <jats:italic>Methods<\/jats:italic>. We isolated T-MSCs from human palatine tonsil and evaluated the ingredients of T-MSCs-CM. The effect of T-MSCs-CM was evaluated in the AR mouse model that was randomly divided into five groups (negative control, positive control, and T-MSCs-CM treated (0.1\u2009mg, 1\u2009mg, and 10\u2009mg)). To investigate the therapeutic effect, we analyzed rhinitis symptoms, serum immunoglobulin (Ig), inflammatory cells, and cytokine expression. We also assessed T cell receptor signal, including MAP kinase (ERK\/JNK), p65, and NFAT1. <jats:italic>Results<\/jats:italic>. We identified the increment of TGF-<jats:italic>\u03b2<\/jats:italic>1, PGE2, and HGF in the T-MSCs-CM. In an animal study, the T-MSCs-CM-treated group showed significantly reduced allergic symptoms and infiltration of eosinophils and neutrophils in the nasal mucosa, whereas there was no significant difference in total IgE and the OVA-specific IgE level. Additionally, we found that the 10\u2009mg T-MSCs-CM-treated group showed a significantly decreased IL-4 mRNA expression, compared to the (+) Con group. In the analysis of T cell receptor signal, the phosphorylation of MAP kinases, translocation of p65, and activation of NFAT1 were inhibited after T-MSCs-CM. <jats:italic>Conclusions<\/jats:italic>. Our findings suggest that T-MSCs-CM showed a partial immunomodulatory effect on the AR mouse model by the inhibition of T cell activation via MAP kinase, p65, and NFAT1.<\/jats:p>","DOI":"10.1155\/2020\/6982438","type":"journal-article","created":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T23:31:34Z","timestamp":1586302294000},"page":"1-7","source":"Crossref","is-referenced-by-count":12,"title":["The Supernatant of Tonsil-Derived Mesenchymal Stem Cell Has Antiallergic Effects in Allergic Rhinitis Mouse Model"],"prefix":"10.1155","volume":"2020","author":[{"given":"In-Su","family":"Park","sequence":"first","affiliation":[{"name":"Ajou University Medical Center, Suwon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hye","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Republic of Korea"},{"name":"Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Sang","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Republic of Korea"},{"name":"Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4917-0177","authenticated-orcid":true,"given":"Dong-Kyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology-Head and Neck Surgery, Chuncheon Sacred Heart Hospital, Chuncheon, Republic of Korea"},{"name":"Institute of New Frontier Research, Hallym University College of Medicine, Chuncheon, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1331-364X","authenticated-orcid":true,"given":"Ji-Hun","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Dankook University College of Medicine, Cheonan, Republic of Korea"},{"name":"Beckman Laser Institute Korea, Dankook University College of Medicine, Cheonan, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01620.x"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.08.049"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22073"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130230"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0394"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/nri2395"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-443-8_4"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.44"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2007.03.001"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/scrt2"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0283"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1002\/stem.656"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02509.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910720107"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.04.016"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16788-2"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/term.2423"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2015.08.001"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25004"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183141"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4216"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1559"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-07-2921"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0315"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3058"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.02.036"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0225739"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.259"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204382"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.8.3405"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.5.953"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a000034"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/nri1632"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1126\/science.1151227"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2020\/6982438.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2020\/6982438.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2020\/6982438.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,7]],"date-time":"2020-04-07T23:31:36Z","timestamp":1586302296000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2020\/6982438\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,7]]},"references-count":34,"alternative-id":["6982438","6982438"],"URL":"https:\/\/doi.org\/10.1155\/2020\/6982438","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,7]]}}}