{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:18:12Z","timestamp":1788905892629,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T00:00:00Z","timestamp":1606348800000},"content-version":"vor","delay-in-days":330,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","award":["TURSP-2020\/111"],"award-info":[{"award-number":["TURSP-2020\/111"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    The incidence of diabetes mellitus has increased in Saudi Arabia, which has raised the risk of vulvovaginal candidiasis (VVC). This study highlights the prevalence and antifungal susceptibility of\n                    <jats:italic>Candida<\/jats:italic>\n                    species among postmenopausal women with diabetes with symptoms of VVC in Taif, a city in Saudi Arabia. Several diagnostic tools were used to differentiate the yeast isolates, including microscopic examination, culture morphology on CHROM agar, further confirmation with the VITEK 2 system, and ITS1 and ITS4 region sequencing. Antifungal susceptibility of the selected\n                    <jats:italic>Candida<\/jats:italic>\n                    species was determined using the VITEK 2 system (bioM\u00e9rieux Inc., USA). Out of the 550 high vaginal swabs investigated, 86 specimens were\n                    <jats:italic>Candida<\/jats:italic>\n                    species positive (15.6%) with a significant difference according to age; the positivity in the 45\u201350 years\u2019 age group (12%) was higher than that in the 51\u201355 years\u2019 age group (3.6%).\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    was the most common causative agent in 51 samples (59.3%), followed by\n                    <jats:italic>C. glabrata<\/jats:italic>\n                    in 21 samples (24.41%) and\n                    <jats:italic>C. krusei<\/jats:italic>\n                    in 14 samples (16.27%), with no significant differences between the age groups. Three isolates, including two\n                    <jats:italic>C. albicans<\/jats:italic>\n                    and one\n                    <jats:italic>C. krusei<\/jats:italic>\n                    , exhibited resistance against all the tested antifungal agents. CHROM agar and VITEK 2 were accurate phenotypic tools to identify\n                    <jats:italic>Candida<\/jats:italic>\n                    species with 100% sensitivity and specificity and were consistent with the phylogenetic characterization. The data emphasized the importance of identifying\n                    <jats:italic>Candida<\/jats:italic>\n                    species and their antifungal susceptibility among postmenopausal women with diabetes, highlighting the potential risk posed by diabetes in this age group.\n                  <\/jats:p>","DOI":"10.1155\/2020\/7042490","type":"journal-article","created":{"date-parts":[[2020,11,26]],"date-time":"2020-11-26T20:50:05Z","timestamp":1606423805000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prevalence and Antifungal Susceptibility Profile of Clinically Relevant\n                    <i>Candida<\/i>\n                    Species in Postmenopausal Women with Diabetes"],"prefix":"10.1155","volume":"2020","author":[{"given":"Sarah","family":"Al Halteet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1933-8197","authenticated-orcid":false,"given":"Ahmed","family":"Abdel-Hadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Awad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,26]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00076-09"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60917-9"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02030.x"},{"key":"e_1_2_9_4_2","first-page":"443","article-title":"Comparison of enzymatic method rapid yeast plus system with RFLP-PCR for identification of isolated yeast from vulvovaginal candidiasis","volume":"14","author":"Hossein M.","year":"2011","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.697053"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3182241f1a"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbu105"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/jinf.2000.0723"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2005.03.005"},{"key":"e_1_2_9_10_2","volume-title":"Fungal infection of the skin and nails","author":"Suhonen R. 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