{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T17:07:46Z","timestamp":1769188066828,"version":"3.49.0"},"reference-count":44,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2020,12,21]]},"abstract":"<jats:p>Ureteral stenosis is a rare manifestation of granulomatosis with polyangiitis (formerly known as Wegener\u2019s granulomatosis). We report the case of a 76-year-old woman with progressive renal failure in which bilateral hydronephrosis due to ureteral stenosis was the first manifestation of the disease. Our patient also had renal involvement with pauci-immune crescentic glomerulonephritis associated with high titers of anti-proteinase 3 c-ANCAs, but no involvement of the upper or lower respiratory tract. The hydronephrosis and renal function rapidly improved under immunosuppressive therapy with high-dose corticosteroids and intravenous pulse cyclophosphamide. We reviewed the literature and found only ten other reported cases of granulomatosis with polyangiitis\/Wegener\u2019s granulomatosis and intrinsic ureteral stenosis: in two cases, the presenting clinical manifestation was unilateral hydronephrosis and in only two others was the hydronephrosis bilateral, but this complication developed during a relapse of the disease. This case emphasizes the importance of including ANCA-related vasculitis in the differential diagnosis of unusual cases of unilateral or bilateral ureteral stenosis.<\/jats:p>","DOI":"10.1155\/2020\/7189497","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T21:06:04Z","timestamp":1608757564000},"page":"1-6","source":"Crossref","is-referenced-by-count":3,"title":["Bilateral Ureteral Stenosis with Hydronephrosis as First Manifestation of Granulomatosis with Polyangiitis (Wegener\u2019s Granulomatosis): A Case Report and Review of the Literature"],"prefix":"10.1155","volume":"2020","author":[{"given":"Joelle","family":"Suillot","sequence":"first","affiliation":[{"name":"Service of Nephrology, HFR Cantonal Hospital Fribourg, Fribourg, Switzerland"},{"name":"University of Fribourg, Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrg","family":"Bollmann","sequence":"additional","affiliation":[{"name":"Service of Urology, HFR Cantonal Hospital Fribourg, Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Rotman","sequence":"additional","affiliation":[{"name":"Service of Clinical Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9307-3246","authenticated-orcid":true,"given":"Eric","family":"Descombes","sequence":"additional","affiliation":[{"name":"Service of Nephrology, HFR Cantonal Hospital Fribourg, Fribourg, Switzerland"},{"name":"University of Fribourg, Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-013-0869-6"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780370206"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.08.017"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.02500317"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2015.05.012"},{"issue":"3","key":"6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/00005792-199505000-00005","article-title":"Urogenital manifestations of Wegener\u2019s granulomatosis","volume":"74","author":"D. 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