{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:11:17Z","timestamp":1790982677370,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T00:00:00Z","timestamp":1580428800000},"content-version":"vor","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Objectives<\/jats:italic>. To explore the differences between primary and redo urethroplasty and to directly compare according stricture\u2010free survival (SFS). <jats:italic>Materials and Methods<\/jats:italic>. Data of all male patients who underwent urethroplasty at Ghent University Hospital were collected between 2000 and 2018. Exclusion criteria for this analysis were age &lt;18 years and follow\u2010up &lt;1 year. Two patient groups were created for further comparison: the primary urethroplasty (PU) group (no previous urethroplasty) and redo urethroplasty (RU) group (\u22651 previous urethroplasty), irrespective of prior endoscopic treatments. A comparison between groups was performed using the Mann\u2013Whitney <jats:italic>U<\/jats:italic> test and Fisher\u2019s Exact test. SFS was calculated using Kaplan\u2013Meier statistics. A functional definition of failure, being the need for further urethral manipulation, was used. Uni\u2010 and multivariate Cox regression analyses were performed on the entire patient cohort. <jats:italic>Results<\/jats:italic>. 805 patients were included. Median (IQR) follow\u2010up of the PU (<jats:italic>n<\/jats:italic>\u2009=\u2009556) and RU (<jats:italic>n<\/jats:italic>\u2009=\u2009249) groups was 87 (50\u2013136) and 76 (40\u2013133) months, respectively (<jats:italic>p<\/jats:italic> = 0.1). The RU group involved more penile strictures (<jats:italic>p<\/jats:italic> &lt; 0.001), Lichen Sclerosus (<jats:italic>p<\/jats:italic> = 0.016), failed hypospadias repair (<jats:italic>p<\/jats:italic> = 0.004), multistage procedures (<jats:italic>p<\/jats:italic> &lt; 0.001), and definitive perineostomies (<jats:italic>p<\/jats:italic> = 0.001). The 5\u2010 and estimated 10\u2010year SFS was, respectively, 86% and 79% for the PU group and, respectively, 75% and 63% for the RU group (<jats:italic>p<\/jats:italic> &lt; 0.001). Prior urethroplasty (HR: 1.52; <jats:italic>p<\/jats:italic> = 0.01) and diabetes (HR: 1.83; <jats:italic>p<\/jats:italic> = 0.03) remained statistically significant in the multivariate Cox regression analysis. <jats:italic>Conclusions<\/jats:italic>. Several differences between primary and redo urethroplasties exist. Redo urethroplasty entails a distinct patient population to treat and is, in general, associated with lower stricture\u2010free survival than primary urethroplasty, although more homogeneous series are required to corroborate these results. Prior urethroplasty and diabetes are independent risk factors for urethroplasty failure.<\/jats:p>","DOI":"10.1155\/2020\/7214718","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T23:34:28Z","timestamp":1580513668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Primary versus Redo Urethroplasty: Results from a Single\u2010Center Comparative 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