{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T17:54:01Z","timestamp":1782842041592,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":355,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Open Research Fund Program of the State Key Laboratory of Virology of China","award":["2020KF006"],"award-info":[{"award-number":["2020KF006"]}]},{"name":"Open Research Fund Program of the State Key Laboratory of Virology of China","award":["JDYY11202018"],"award-info":[{"award-number":["JDYY11202018"]}]},{"name":"First Hospital of Jilin University, Youth Development Foundation","award":["2020KF006"],"award-info":[{"award-number":["2020KF006"]}]},{"name":"First Hospital of Jilin University, Youth Development Foundation","award":["JDYY11202018"],"award-info":[{"award-number":["JDYY11202018"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background and Aims<\/jats:italic>. Alcohol\u2010associated liver disease is exhibiting an increasing disease burden. In terms of pathogenesis, inflammation is closely related to alcohol\u2010induced liver injury. The neutrophil\u2010to\u2010lymphocyte ratio (NLR) is a novel inflammatory biomarker. Here, we aim to evaluate the role of the NLR and other biomarkers in predicting short\u2010term mortality in alcoholic cirrhotic patients. <jats:italic>Methods<\/jats:italic>. This was a retrospective study that included 459 male alcoholic cirrhosis patients. Among them, 345 patients completed follow\u2010up. Based on their 30\u2010day mortality information, patients were separated into surviving and nonsurviving groups. Demographic, clinical, and biochemical features were collected for further analysis. Logistic regression was used to identify factors associated with short\u2010term mortality, and receiver operating characteristic (ROC) curve analysis was used to establish the predictive value of these factors. <jats:italic>Results<\/jats:italic>. The prognostic scores were significantly higher in the nonsurviving group than in the surviving group: NLR: 5.5 vs. 3.2 (<jats:italic>P<\/jats:italic> &lt; 0.001), model for end\u2010stage liver disease (MELD): 15.4 vs. 7.9 (<jats:italic>P<\/jats:italic> &lt; 0.001), Maddrey\u2019s discriminant function (MDF): 39.8 vs. 12.7 (<jats:italic>P<\/jats:italic> &lt; 0.001), and the integrated MELD (i\u2010MELD): 37.9 vs. 28.4 (<jats:italic>P<\/jats:italic> &lt; 0.001). Logistic regression demonstrated that albumin (ALB), NLR, and i\u2010MELD values were significantly correlated with patient death in 30 days. On ROC analysis, the diagnostic accuracy for 30\u2010day mortality of the NLR (area under the ROC curve (AUROC) of 0.72, <jats:italic>P<\/jats:italic> &lt; 0.001) was similar to that of the MELD or i\u2010MELD (AUROCs of 0.71 and 0.74, respectively, <jats:italic>P<\/jats:italic> &lt; 0.001). The new biomarker, NLA, calculated as 100 \u00d7 NLR\/ALB, had the best prognostic value. The cutoff values of the NLR and NLA for predicting 30\u2010day mortality were 4.2 and 19.6, respectively. <jats:italic>Conclusions<\/jats:italic>. The NLR and its related biomarker NLA are simple and robust predictors of 30\u2010day mortality in alcoholic cirrhosis patients.<\/jats:p>","DOI":"10.1155\/2020\/7268459","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T03:05:27Z","timestamp":1608606327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Neutrophil\u2010to\u2010Lymphocyte Ratio and Albumin: New Serum Biomarkers to Predict the Prognosis of Male Alcoholic Cirrhosis 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