{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:56:08Z","timestamp":1793393768772,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T00:00:00Z","timestamp":1588723200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taizhou Science and Technology Support Plan","award":["TS202014"],"award-info":[{"award-number":["TS202014"]}]},{"name":"Taizhou Science and Technology Support Plan","award":["TS201801"],"award-info":[{"award-number":["TS201801"]}]},{"name":"Taizhou Science and Technology Support Plan","award":["TS202014"],"award-info":[{"award-number":["TS202014"]}]},{"name":"Taizhou Science and Technology Support Plan","award":["TS201801"],"award-info":[{"award-number":["TS201801"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2020,5,6]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. This study is aimed at investigating whether albumin-to-fibrinogen ratio (AFR) could independently predict the prognosis in patients with peritonitis-induced sepsis. <jats:italic>Methods<\/jats:italic>. A total of 246 eligible patients who were scheduled to undergo surgical treatment for peritonitis-induced sepsis were enrolled in this study. The primary observational endpoint was 28-day hospital mortality. Cox proportional hazards regression analysis with the Wald test was performed to identify prognostic factors for 28-day mortality in septic patients. Receiver operating characteristic (ROC) and Kaplan-Meier curve analyses were carried out to evaluate the association of baseline AFR and prognosis in septic patients. <jats:italic>Results<\/jats:italic>. Of all the cohort study participants, there were 59 nonsurvivors with a 28-day mortality of 24.0% (59\/246). Baseline AFR (hazard ratio (HR): 0.67, 95% confidence interval (CI): 0.42\u20130.93, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.018<\/mml:mn><\/mml:math>) and the presence of septic shock (HR: 2.43, 95% CI: 1.42\u20133.91, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.021<\/mml:mn><\/mml:math>) were two independent prognostic factors for 28-day mortality in patients with peritonitis-induced sepsis by multivariate Cox analysis. Baseline AFR was a significant predictor for 28-day mortality with an area under the curve (AUC) of 0.751, a cut-off value of 8.85, a sensitivity of 66.10%, and a specificity of 70.05%, respectively (95% CI: 0.688\u20130.813, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). A low baseline AFR level (\u22648.85) was significantly associated with a lower overall survival rate in septic patients by Kaplan-Meier curve analysis with log-rank test (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. This study indicates that AFR independently predicts 28-day mortality in patients with peritonitis-induced sepsis.<\/jats:p>","DOI":"10.1155\/2020\/7280708","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T23:34:40Z","timestamp":1588808080000},"page":"1-7","source":"Crossref","is-referenced-by-count":29,"title":["Albumin-to-Fibrinogen Ratio Independently Predicts 28-Day Mortality in Patients with Peritonitis-Induced Sepsis"],"prefix":"10.1155","volume":"2020","author":[{"given":"Huiyu","family":"Tai","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit, Taizhou People\u2019s Hospital, Medical School of Nantong University, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Taizhou People\u2019s Hospital, Medical School of Nantong University, 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