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Obstructive sleep apnea (OSA) is closely related to the incidence and progression of coronary artery disease (CAD), and the mechanisms linking OSA and CAD are multifactorial. C1q\/TNF-related protein-9 (CTRP9) is a novel adipokine that protects the heart against ischemic injury and ameliorates cardiac remodeling. We aimed to ascertain the clinical relevance of CTRP9 with OSA prevalence in patients with CAD. <jats:italic>Methods<\/jats:italic>. From August 2016 to March 2019, consecutive eligible patients with CAD (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>154<\/mml:mn><\/mml:math>; angina pectoris, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>88<\/mml:mn><\/mml:math>; acute myocardial infarction [AMI], <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>66<\/mml:mn><\/mml:math>) underwent cardiorespiratory polygraphy. OSA was defined as an apnea-hypopnea index (AHI) \u226515 events\u00b7h<jats:sup>\u22121<\/jats:sup>. Plasma CTRP9 concentrations were measured by ELISA method. <jats:italic>Results<\/jats:italic>. Moderate\/severe OSA was present in 89 patients (57.8%). CTRP9 levels were significantly decreased in the moderate\/severe OSA group than in the no\/mild OSA group (4.7 [4.1-5.2] ng\/mL vs. 4.9 [4.4-6.0] ng\/mL, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>). The difference between groups was only observed in patients with AMI (3.0 [2.3-4.9] vs. 4.5 [3.2-7.9], <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.009<\/mml:mn><\/mml:math>). Correlation analysis showed that CTRP9 levels were negatively correlated with AHI (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>\u2212<\/mml:mo><mml:mn>0.238<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:math>) and oxygen desaturation index (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mo>\u2212<\/mml:mo><mml:mn>0.234<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:math>) and positively correlated with left ventricular ejection fraction (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>r<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.251<\/mml:mn><\/mml:math>, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:math>) in all subjects. Multivariate analysis showed that male gender (OR 3.099, 95% CI 1.029-9.330, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.044<\/mml:mn><\/mml:math>), BMI (OR 1.148, 95% CI 1.040-1.268, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.006<\/mml:mn><\/mml:math>), and CTRP9 levels (OR 0.726, 95% CI 0.592-0.890, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>) were independently associated with the prevalence of moderate\/severe OSA. <jats:italic>Conclusions<\/jats:italic>. Plasma CTRP9 levels were independently related to the prevalence of moderate\/severe OSA in patients with CAD, suggesting that CTRP9 might play a role in the pathogenesis of CAD exacerbated by OSA.<\/jats:p>","DOI":"10.1155\/2020\/7281391","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T23:43:27Z","timestamp":1596671007000},"page":"1-8","source":"Crossref","is-referenced-by-count":5,"title":["Association of C1q\/TNF-Related Protein-9 (CTRP9) Level with Obstructive Sleep Apnea in Patients with Coronary Artery Disease"],"prefix":"10.1155","volume":"2020","author":[{"given":"Zexuan","family":"Li","sequence":"first","affiliation":[{"name":"Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhui","family":"Du","sequence":"additional","affiliation":[{"name":"Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing, 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