{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:18:28Z","timestamp":1753881508275,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T00:00:00Z","timestamp":1586131200000},"content-version":"vor","delay-in-days":96,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81774238","81373563"],"award-info":[{"award-number":["81774238","81373563"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Cyclooxygenase\u20102 (COX\u20102) is an inducible enzyme stimulated by various inflammatory factors (IFs). Chronic gastritis is a classic model of \u201cinflammation\u2010cancer transformation\u201d and <jats:italic>Helicobacter pylori<\/jats:italic>\u2010related gastric diseases (HPGD) are specific ones of this model. Traditional Chinese Medicine (TCM) syndromes could play a predictive role in gastric histopathological evolution. To search for early warning evidence about \u201cinflammation\u2010cancer transformation,\u201d this study is about to explore interaction of COX\u20102 with <jats:italic>H<\/jats:italic>e<jats:italic>licobacter pylori<\/jats:italic> (Hp) in HPGD with different TCM syndromes. All included subjects underwent endoscopy and biopsy. Hp infection was detected by rapid urease test and methylene blue staining. Histopathological characteristics and COX\u20102 expression in gastric mucosa (GM) were, respectively, observed by hematoxylin\u2010eosin and Elivision\u2122 plus. SPSS 18.0 and Stata 11.0 statistical software packages were used for statistical analysis. Results of immunohistochemical staining in this study showed COX\u20102 expression in Hp\u2010positive patients was stronger than that in Hp\u2010negative ones. Spearman\u2019 analysis indicated that degrees of both Hp infection and COX\u20102 expression were positively correlated with those of gastric inflammation and inflammatory activity. Compared with the relative normal group, both severe dysplasia group and gastric carcinoma group had more severe Hp infection and COX\u20102 expression. Compared with the nonsyndrome, syndrome of internal block of static blood (IBSB) had higher scores in semiquantitative analysis of COX\u20102 protein expression among TCM groups. Moreover, multivariate logistics regression analysis suggested that patients with Hp infection could increase the risk of IBSB. These results indicated that COX\u20102 interacting with Hp could play an important role in transforming gastric chronic nonresolving inflammation into carcinoma in subjects with HPGD, as well as inducing the formation of IBSB. HPGD together with IBSB could be an early warning evidence for GM with histopathological evolution from benign to malignant.<\/jats:p>","DOI":"10.1155\/2020\/7340814","type":"journal-article","created":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T23:31:13Z","timestamp":1586215873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Interaction of Cyclooxygenase\u20102 with <i>Helicobacter pylori<\/i> Induces Gastric Chronic Nonresolving Inflammation and the Formation of Syndrome of Internal Block of Static Blood in <i>Helicobacter pylori<\/i>\u2010Related Gastric Diseases"],"prefix":"10.1155","volume":"2020","author":[{"given":"Yun-kai","family":"Dai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-zhan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8923-3449","authenticated-orcid":false,"given":"Dan-yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao-yang","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-yu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng-xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-tong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru-liu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3104-8050","authenticated-orcid":false,"given":"Ling","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,6]]},"reference":[{"key":"e_1_2_10_1_2","first-page":"3554","article-title":"A human model of gastric carcinogenesis","volume":"48","author":"Correa P.","year":"1988","journal-title":"Cancer Research"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.15403\/jgld.2014.1121.271.pep"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.00005"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/165.1.21"},{"key":"e_1_2_10_5_2","first-page":"20","article-title":"The association between Helicobacter pylori and gastric neoplasia","volume":"65","author":"Guarner J.","year":"2000","journal-title":"Epidemiologic Evidence. 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