{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T23:42:12Z","timestamp":1771544532494,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T00:00:00Z","timestamp":1585008000000},"content-version":"vor","delay-in-days":83,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Science and Technology Innovation Action Medical Key Program","award":["1341195400"],"award-info":[{"award-number":["1341195400"]}]},{"name":"Shanghai Science and Technology Innovation Action Medical Key Program","award":["2019YFC0840607"],"award-info":[{"award-number":["2019YFC0840607"]}]},{"name":"National Key R&D Program of China","award":["1341195400"],"award-info":[{"award-number":["1341195400"]}]},{"name":"National Key R&D Program of China","award":["2019YFC0840607"],"award-info":[{"award-number":["2019YFC0840607"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To evaluate the influence of systemic and ocular factors on the foveal avascular zone (FAZ) area in young Chinese subjects\u2019 healthy eyes. <jats:italic>Methods<\/jats:italic>. The current observational, cross\u2010sectional study included 344 eyes from 172 healthy individuals (103 women, 69 men). Optical coherence tomography angiography realized with the split\u2010spectrum amplitude\u2010decorrelation angiography (SSADA) algorithm was used to assess the area of superficial FAZ. To determine the related factors and to reveal their potential correlations with the FAZ area, comprehensive examinations including both systemic and ocular ones were executed. Systemic examination involved factors including age, gender, and body mass index, while ocular examination involved factors including BCVA, refractive error, intraocular pressure, axial length (AL), anterior chamber depth, and central corneal thickness. Especially for fundus examination, central macular thickness (CMT), retinal volume, mean retinal thickness, macular blood flow area\/vessel density in the superficial retinal layer (SRL) and deep retinal layer (DRL), mean retinal nerve fiber layer (RNFL) thickness, ganglion cell layer (GCL) thickness, C\/D rate, rim area, and subfoveal choroid thickness were assessed, using mixed\u2010effects regression models to appropriately account for intereye correlation. Subgroup analyses were performed based on gender and high myopia categories. <jats:italic>Results<\/jats:italic>. The mean FAZ area was 0.30 \u00b1 0.11\u2009mm<jats:sup>2<\/jats:sup> and varied significantly across gender (<jats:italic>P<\/jats:italic> = 0.0024). AL, CMT, and RNFL thickness were found significantly correlated with the FAZ area in the univariate regression analysis (AL, <jats:italic>P<\/jats:italic> = 0.0005; CMT, <jats:italic>P<\/jats:italic> &lt; 0.0001; and RNFL thickness, <jats:italic>P<\/jats:italic> = 0.0461). According to the multivariate results, CMT and macular blood flow in SRL were negatively correlated with FAZ (CMT: <jats:italic>P<\/jats:italic> &lt; 0.0001; macular blood flow in SRL: <jats:italic>P<\/jats:italic> = 0.00223). Mean retinal thickness, mean GCL thickness, and macular blood flow in DRL were positively correlated with FAZ (mean retinal thickness: <jats:italic>P<\/jats:italic> = 0.0005; mean GCL thickness: <jats:italic>P<\/jats:italic> &lt; 0.0001; and macular blood flow in DRL: <jats:italic>P<\/jats:italic> = 0.0099). Correlation results among these filtered factors and FAZ were more pronounced in non\u2010high\u2010myopic eyes than in high\u2010myopic eyes and had a significant difference when data of male and female subjects were processed separately from each other. <jats:italic>Conclusion<\/jats:italic>. The present cross\u2010sectional study performed comprehensive systemic and ocular examinations in young Chinese adults and filtered factors affecting FAZ. We indicated that among all the assessed candidate factors, gender, AL, retinal thickness, macular blood flow, RNFL, and GCL thickness affected the FAZ area most significantly. Such findings would facilitate future research concerning the role of FAZ variation in fundus diseases.<\/jats:p>","DOI":"10.1155\/2020\/7361492","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T23:31:27Z","timestamp":1585092687000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Factors Affecting the Foveal Avascular Zone Area in Healthy Eyes among Young Chinese 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