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The aim of this study is to evaluate the prognostic value of autophagy-related genes in patients with head and neck squamous cell carcinoma (HNSCC). Transcriptome expression profiles and clinical data acquired from The Cancer Genome Atlas (TCGA) database were analyzed by Cox proportional hazards model and Kaplan\u2013Meier survival analysis to screen autophagy-related prognostic genes that were significantly correlated with HNSCC patients\u2019 overall survival. Functional enrichment analyses were performed to explore biological functions of differentially expressed autophagy-related genes (ARGs) identified in HNSCC patients. Six ARGs (EGFR, HSPB8, PRKN, CDKN2A, FADD, and ITGA3) identified with significantly prognostic values for HNSCC were used to construct a risk signature that could stratify patients into the high-risk and low-risk groups. This signature demonstrated great value in predicting prognosis for HNSCC patients and was indicated as an independent prognostic factor in terms of clinicopathological characteristics (sex, age, clinical stage, histological grade, anatomic subdivision, alcohol history, smoking status, HPV status, and mutational status of the samples). The prognostic signature was also validated by data from the Gene Expression Omnibus (GEO) database and International Cancer Genome Consortium (ICGC). In conclusion, this study provides a novel autophagy-related gene signature for predicting prognosis of HNSCC patients and gives molecular insights of autophagy in HNSCC.<\/jats:p>","DOI":"10.1155\/2020\/7397132","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T02:35:08Z","timestamp":1609295708000},"page":"1-23","source":"Crossref","is-referenced-by-count":18,"title":["Prognostic Correlation of an Autophagy-Related Gene Signature in Patients with Head and Neck Squamous Cell Carcinoma"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6677-0532","authenticated-orcid":true,"given":"Cai","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8462-638X","authenticated-orcid":true,"given":"Hongxiang","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9831-2787","authenticated-orcid":true,"given":"Liang","family":"Peng","sequence":"additional","affiliation":[{"name":"Intelligent Information Technologies and Applications Lab (IIT), School of Information and Software Engineering, University of Electronic Science and Technology of China, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1332-6504","authenticated-orcid":true,"given":"Fulin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2916-3359","authenticated-orcid":true,"given":"Bingjie","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8320-2406","authenticated-orcid":true,"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, West China Hospital of Stomatology, West China School of Stomatology, Sichuan University, State Key Laboratory of Oral Diseases, Chengdu 610041, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"doi-asserted-by":"publisher","key":"1","DOI":"10.1001\/jamaoncol.2019.2996"},{"doi-asserted-by":"publisher","key":"2","DOI":"10.3322\/caac.21332"},{"doi-asserted-by":"publisher","key":"3","DOI":"10.1016\/j.oraloncology.2013.12.008"},{"doi-asserted-by":"publisher","key":"4","DOI":"10.1634\/theoncologist.2009-0289"},{"doi-asserted-by":"publisher","key":"5","DOI":"10.1016\/S0140-6736(08)60728-X"},{"doi-asserted-by":"publisher","key":"6","DOI":"10.1016\/j.cell.2018.09.048"},{"doi-asserted-by":"publisher","key":"7","DOI":"10.1101\/gad.287524.116"},{"doi-asserted-by":"publisher","key":"8","DOI":"10.1080\/15548627.2018.1450020"},{"doi-asserted-by":"publisher","key":"9","DOI":"10.3390\/cells8121656"},{"key":"10","first-page":"2825","article-title":"Scikit-learn: machine learning in python","volume":"12","author":"F. 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