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This study was firstly conducted to investigate whether resveratrol could alleviate IUGR\u2010induced hepatic lipid accumulation, alteration of redox and immune status in a sucking piglet model and explore the possible mechanisms at transcriptional levels. A total of 36 pairs of 7\u2009d old male normal birth weight (NBW) and IUGR piglets were orally fed with either 80\u2009mg resveratrol\/kg body weight\/d or 0.5% carboxymethylcellulose sodium for a period of 14 days, respectively. Compared with the NBW piglets, the IUGR piglets displayed compromised growth performance and liver weight, reduced plasma free fatty acid (FFA) level, increased hepatic OS, abnormal hepatic lipid accumulation and weakened hepatic immune function, and hepatic aberrant transcriptional expression of some genes such as heme oxygenase 1, superoxide dismutase 1, sterol regulatory element\u2010binding protein 1c, stearoyl\u2010CoA desaturase 1, liver fatty acid\u2010binding proteins 1, toll\u2010like receptor 4, and tumor necrosis factor alpha (TNF\u2010<jats:italic>\u03b1<\/jats:italic>). Oral administration of resveratrol to piglets decreased the levels of FFA and total triglycerides (TG) in the plasma and hepatic TNF\u2010<jats:italic>\u03b1<\/jats:italic> concentration, and increased glutathione reductase activity and reduced glutathione level in the liver. Resveratrol restored the increased alanine aminotransferase activity in the plasma of IUGR piglets. Treatment with resveratrol ameliorated the increased hepatic malondialdehyde, protein carbonyl, TG, and FFA concentrations induced by IUGR. Resveratrol treatment alleviated the reduced lipoprotein lipase activity and its mRNA expression as well as TNF\u2010<jats:italic>\u03b1<\/jats:italic> gene expression in the liver of IUGR piglets. Hepatic glutathione peroxidase 1 and monocyte chemotactic protein 1 genes expression of piglets was upregulated by oral resveratrol administration. In conclusion, resveratrol administration plays a beneficial role in hepatic redox status and lipid balance of the IUGR piglets.<\/jats:p>","DOI":"10.1155\/2020\/7402645","type":"journal-article","created":{"date-parts":[[2020,7,18]],"date-time":"2020-07-18T23:31:48Z","timestamp":1595115108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Resveratrol Improves Hepatic Redox Status and Lipid Balance of Neonates with Intrauterine Growth Retardation in a Piglet 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