{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:43:17Z","timestamp":1780591397561,"version":"3.54.1"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":316,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2011\/01\/B\/NZ6\/00264"],"award-info":[{"award-number":["2011\/01\/B\/NZ6\/00264"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>\n                    <jats:italic>Yersinia enterocolitica<\/jats:italic>\n                    O:3 is mentioned among the most common arthritogenic pathogens. Bacterial components (including lipopolysaccharide (LPS)) may persist in the joint after eradication of infection. Having an adjuvant activity, LPS may enhance production of anticollagen antibodies, involved in the pathogenesis of rheumatoid arthritis. Furthermore, its ability to activate complement contributes to the inflammation. The aim of this work was to investigate whether\n                    <jats:italic>Yersinia<\/jats:italic>\n                    LPS (coinjected with collagen) is associated with arthritis progression or other pathological effects and to elucidate the mechanism of this association. It was demonstrated that murine mannose\u2010binding lectin C (MBL\u2010C) recognizes the inner core heptoses of the Rd1 chemotype LPS of\n                    <jats:italic>Yersinia.<\/jats:italic>\n                    In addition, the Rd1 LPS activates the MBL\u2010associated serine protease 1 (MASP\u20101) stronger than the S and Ra chemotype LPS and comparable to\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    O:3 LPS. However, in contrast to the latter,\n                    <jats:italic>Yersinia<\/jats:italic>\n                    Rd1 LPS was associated neither with the adjuvancity nor with the enhancement of pathological changes in animal paws\/impairment of motility. On the other hand, it seemed to be more hepatotoxic when compared with the other tested endotoxins, while the enlargement of inguinal lymph nodes and drop in hepatic MBL\u2010C expression (at the mRNA level) were independent of LPS chemotype. Our data did not suggest no greater impact\n                    <jats:italic>Y<\/jats:italic>\n                    .\n                    <jats:italic>enterocolitica<\/jats:italic>\n                    O:3 on the development or severity of arthropathy related to anticollagen antibody\u2010induced arthritis in mice, although its interaction with MBL\u2010C and subsequent complement activation may contribute to some adverse effects.\n                  <\/jats:p>","DOI":"10.1155\/2020\/7439506","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T14:50:53Z","timestamp":1605192653000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The Role of\n                    <i>Yersinia enterocolitica<\/i>\n                    O:3 Lipopolysaccharide in Collagen\u2010Induced 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