{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:31:43Z","timestamp":1784608303612,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":233,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013335","name":"National Key Basic Research Program For Youth","doi-asserted-by":"publisher","award":["2014CB543100"],"award-info":[{"award-number":["2014CB543100"]}],"id":[{"id":"10.13039\/501100013335","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010211","name":"Education Department of Jilin Province","doi-asserted-by":"publisher","award":["2016134"],"award-info":[{"award-number":["2016134"]}],"id":[{"id":"10.13039\/501100010211","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>Accumulating evidence suggests that sleep deprivation (S\u2010Dep) is a critical risk factor for depression. Electroacupuncture (EA) treatment has been reported to ameliorate posttraumatic stress disorder\u2010 (PSTD\u2010) like behavior and enhance hippocampal neurogenesis. However, whether EA treatment has any beneficial effect on S\u2010Dep\u2010induced depression\u2010like behavior is still unknown. In the present study, we focused on whether EA at Baihui (GV20) can ameliorate the deterioration effect of S\u2010Dep in mice. Mice were randomly divided into normal, S\u2010Dep, S\u2010Dep\u2009+\u2009EA, and S\u2010Dep\u2009+\u2009sham EA groups. Cognitive behavior test and in vitro assay were performed separately to avoid the influence of behavior test on synaptic transmission and protein expression. Depression\u2010like behaviors were determined by forced swimming test (FST), tail suspension test (TST), and Morris water maze (MWM). Neurogenesis was identified by BrdU, DCX, and NeuN immunofluorescence staining. In vitro long\u2010term potentiation was detected by high frequency stimulation (HFS) at Schaffer collateral\u2010CA1 synapses in hippocampal slices. Brain\u2010derived neurotropic factor (BDNF) and tropomyosin receptor kinase B (TrkB) protein expression level were assayed by western blot. Our results indicated that D\u2010Sep mice demonstrated depression\u2010like behaviors determined by prolonged immobility duration in FST and TST; D\u2010Sep mice also manifested spatial memory retention deficit in MWM. Furthermore, EA treatment ameliorated D\u2010Sep\u2010induced depression\u2010like behaviors and spatial memory retention deficit. Mechanically, EA treatment alleviated neuron progenitor cell proliferation and differentiation, ameliorated the field excitatory postsynaptic potentials (fEPSPs) slope impaired by S\u2010Dep, and elevated BDNF\/TrkB protein expression. Taken together, our data suggested that EA treatment has a protective effect on S\u2010Dep\u2010induced depression\u2010like behavior and cognitive impairment, which may be through regulating BDNF\/TrkB protein expression.<\/jats:p>","DOI":"10.1155\/2020\/7481813","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T23:33:30Z","timestamp":1598052810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of Electroacupuncture at GV20 on Sleep Deprivation\u2010Induced Depression\u2010Like Behavior in Mice"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6891-4410","authenticated-orcid":false,"given":"Xiaohong","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6929-4866","authenticated-orcid":false,"given":"Peng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7459-0336","authenticated-orcid":false,"given":"Hongyan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6402-3015","authenticated-orcid":false,"given":"Fuchun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0077-1"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.7554\/elife.13424"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2019.01.003"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms12455"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2017.05.002"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-017-0510-4"},{"key":"e_1_2_9_7_2","article-title":"Acupuncture for depression","volume":"3","author":"Smith C. 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