{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:40:27Z","timestamp":1787676027931,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Nephrology"],"published-print":{"date-parts":[[2020,12,22]]},"abstract":"<jats:p>Background. To measure International Normalized Ratio (INR) in hemodialysis patients with tunneled dialysis catheters (TDCs), blood sampling is frequently obtained via the catheter at the start of the session. INR measurements via finger-prick point of care testing (POCT) and via blood sampling taken from the dialysis circuit are evaluated as alternatives. Methods. In 14 hemodialysis patients with TDCs, treated with vitamin K antagonists (VKA), INR measurements via POCT were compared with plasma INR samples taken via the catheter at the start of dialysis and via the dialysis circuit after 30 and 60 minutes during 3 nonconsecutive dialysis sessions. Results. Blood samples taken at the start of dialysis at the catheter site were frequently contaminated with heparin originating from the locking solution (unfractionated heparin concentration (UFH) &gt;1.0\u2009IU\/ml in 13.2%). POCT INR at the start of dialysis was not different from plasma INR after 30 and 60\u2009minutes (Wilcoxon test <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.113<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, n\u2009=\u200937, and <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.631<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, n\u2009=\u200936, respectively). Moreover, there was no difference between POCT INR at the start of dialysis and POCT INR after 30 and 60\u2009minutes (Wilcoxon test <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.797<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula> and p\u2009=\u20090.801, respectively; n\u2009=\u200936). Passing and Bablok regression equation was used, y\u2009=\u20090.460\u2009+\u20090.733x; n\u2009=\u2009105. Treatment decisions based on these 2 methods showed a very good overall agreement (kappa\u2009=\u20090.810; 95% CI: 0.732\u20130.889; n\u2009=\u2009105). Conclusions. Measuring plasma INR via the TDC at the start of dialysis should be abandoned. Measuring POCT INR via a finger prick at the start or even after 30 to 60 minutes is an alternative. The most elegant alternative is to take plasma INR samples via the dialysis circuit 30 minutes or later after the start of the dialysis.<\/jats:p>","DOI":"10.1155\/2020\/7586437","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T20:35:08Z","timestamp":1608669308000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["A New Method for the Measurement of International Normalized Ratio in Hemodialysis Patients with Heparin-Locked Tunneled Dialysis Catheters"],"prefix":"10.1155","volume":"2020","author":[{"given":"C\u00e9line B.","family":"Seghers","sequence":"first","affiliation":[{"name":"Department of Nephrology, GZA Ziekenhuizen, Campus Sint-Augustinus, Oosterveldlaan 24, Wilrijk 2610, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6636-1771","authenticated-orcid":true,"given":"Kristien","family":"Ver Elst","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, GZA Ziekenhuizen, Campus Sint-Augustinus, Oosterveldlaan 24, Wilrijk 2610, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0831-4114","authenticated-orcid":true,"given":"Jolien","family":"Claessens","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, GZA Ziekenhuizen, Campus Sint-Augustinus, Oosterveldlaan 24, Wilrijk 2610, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0443-2364","authenticated-orcid":true,"given":"Steven","family":"Weekx","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, GZA Ziekenhuizen, Campus Sint-Augustinus, Oosterveldlaan 24, Wilrijk 2610, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3839-2444","authenticated-orcid":true,"given":"Sigrid","family":"Vermeiren","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, GZA Ziekenhuizen, Campus Sint-Augustinus, Oosterveldlaan 24, Wilrijk 2610, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1256-4818","authenticated-orcid":true,"given":"Manu","family":"Henckes","sequence":"additional","affiliation":[{"name":"Department of Nephrology, GZA Ziekenhuizen, Campus Sint-Augustinus, Oosterveldlaan 24, Wilrijk 2610, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr341"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.04550511"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2008080824"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfx199"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.477"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs485"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-309266"},{"issue":"21","key":"8","first-page":"e1","article-title":"AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American college of cardiology\/American heart association task force on practice guidelines and the heart rhythm society","volume":"64","author":"C. 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