{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T18:28:13Z","timestamp":1749061693083,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Astellas and Viracor-Eurofins"},{"name":"Brown Physicians Inc. Academic Assessment Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hepatology"],"published-print":{"date-parts":[[2020,1,30]]},"abstract":"<jats:p>Despite significant advances in transplantation of HIV-infected individuals, little is known about HIV coinfected patients with hepatitis C virus (HCV) genotypes other than genotype 1, especially when receiving HCV-infected organs with a different genotype. We describe the first case of kidney transplantation in a man coinfected with hepatitis C and HIV in our state. To our knowledge, this is also the first report of an HIV\/HCV\/HBV tri-infected patient with non-1 (2a) HCV genotype who received an HCV-infected kidney graft with the discordant genotype (1a), to which he converted after transplant. Our case study highlights the following: (1) transplant centers need to monitor wait times for an HCV-infected organ and regularly assess the risk of delaying HCV antiviral treatment for HCV-infected transplant candidates in anticipation of the transplant from an HCV-infected donor; (2) closer monitoring of tacrolimus levels during the early phases of anti-HCV protease inhibitor introduction and discontinuation may be indicated; (3) donor genotype transmission can occur; (4) HIV\/HCV coinfected transplant candidates require a holistic approach with emphasis on the cardiovascular risk profile and low threshold for cardiac catheterization as part of their pretransplant evaluation.<\/jats:p>","DOI":"10.1155\/2020\/7679147","type":"journal-article","created":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:51:32Z","timestamp":1582159892000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Successful Kidney Transplantation in a Recipient Coinfected with Hepatitis C Genotype 2 and HIV from a Donor Infected with Hepatitis C Genotype 1 in the Direct-Acting Antiviral Era"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8489-108X","authenticated-orcid":true,"given":"Dimitrios","family":"Farmakiotis","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Brown Alpert Medical School, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Brown Alpert Medical School, Providence, RI, USA"},{"name":"Division of Infectious Diseases, Brigham and Women\u2019s Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy L.","family":"Brotherton","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The Miriam Hospital, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7774-0440","authenticated-orcid":true,"given":"Paul","family":"Morrissey","sequence":"additional","affiliation":[{"name":"Department of Surgery (Transplantation), Brown Alpert Medical School, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reginald","family":"Gohh","sequence":"additional","affiliation":[{"name":"Division of Nephrology (Transplantation), Department of Internal Medicine, Brown Alpert Medical School, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kendra","family":"Vieira","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Brown Alpert Medical School, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn E.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Brown Alpert Medical School, Providence, RI, USA"},{"name":"CODAC Behavioral Health, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"Garland","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Brown Alpert Medical School, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13220"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1001197"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13532"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.10414.1"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12765"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000001336"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15239"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2010060668"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000001410"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15040"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13697"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v22.i4.1650"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000000847"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/tp.0000000000001618"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1056\/nejmc1705221"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.7326\/m17-2871"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1812406"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201712-2614le"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.14381"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s11904-010-0071-3"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0b013e32830e6d51"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1042\/cs20080532"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.01211-09"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.06.040"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12847"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1097\/qai.0b013e31824bb720"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1086\/630210"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(17)33095-7"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.06.017"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1293.2009.00815.x"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1097\/qad.0b013e32833ce54d"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12725"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12447"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2012.02953.x"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1016\/s2352-3018(18)30043-2"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.671"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50264"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.0297"}],"container-title":["Case Reports in Hepatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihep\/2020\/7679147.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihep\/2020\/7679147.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihep\/2020\/7679147.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,20]],"date-time":"2020-02-20T00:51:59Z","timestamp":1582159919000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihep\/2020\/7679147\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,30]]},"references-count":38,"alternative-id":["7679147","7679147"],"URL":"https:\/\/doi.org\/10.1155\/2020\/7679147","relation":{},"ISSN":["2090-6587","2090-6595"],"issn-type":[{"type":"print","value":"2090-6587"},{"type":"electronic","value":"2090-6595"}],"subject":[],"published":{"date-parts":[[2020,1,30]]}}}