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pathogenesis and progression of autoimmune diseases and may predispose to an early stage of general autoimmune susceptibility. Recent studies have been conducted to investigate the association between macrophage migration inhibitory factor- (MIF-) 173G\/C gene polymorphism and autoimmune diseases; however, the results were not exactly identical. In the present study, a systematic review and meta-analysis of case-control studies was performed to estimate the relationship. A comprehensive search of PubMed, Ebsco, EMbase, WanFang databases and CNKI was done. Odds ratio (ORs) and corresponding 95% confidence intervals (CIs) were combined to pool the effect size. The publication bias was examined by Begg\u2019s funnel plots and Egger\u2019s test. RevMan 5.3 and STATA 12.0 software were used for statistical processing. 23 papers were included, and the results revealed that MIF-173G\/C was significantly associated with an increased risk of autoimmune diseases in five genetic models (recessive genetic model: <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.95<\/mml:mn><\/mml:math>, 95% CI: 1.52-2.50; dominant genetic model: <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.35<\/mml:mn><\/mml:math>, 95% CI: 1.24-1.46; allele model: <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.32<\/mml:mn><\/mml:math>, 95% CI: 1.23-1.41; homozygote model: <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.92<\/mml:mn><\/mml:math>, 95% CI: 1.57-2.35; heterozygote model: <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mtext>OR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>4.92<\/mml:mn><\/mml:math>, 95% CI: 4.03-6.02), whether in Asia, Europe, or North America. Furthermore, subgroup analysis showed an increasing risk in rheumatoid arthritis (RA), ulcerative colitis (UC), Crohn\u2019s disease (CD), atopic dermatitis (AD), Henoch-Schonlein purpura (HSP), and Henoch-Schonlein purpura nephritis (HSPN), but it was not related to the susceptibility of autoimmune hepatitis (AIH). Therefore, it could be considered that MIF-173G\/C polymorphism could increase the susceptibility of autoimmune diseases, while there may be the discrepancy of disease entity.<\/jats:p>","DOI":"10.1155\/2020\/7825072","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T23:31:32Z","timestamp":1588116692000},"page":"1-12","source":"Crossref","is-referenced-by-count":11,"title":["The Role of MIF-173G\/C Gene Polymorphism in the Susceptibility of Autoimmune Diseases"],"prefix":"10.1155","volume":"2020","author":[{"given":"Xiangrong","family":"Du","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, Binzhou Medical University Hospital, 661 Second Huanghe Road, Binzhou 256603, China"},{"name":"Department of Internal Medicine, Linzi District People\u2019s Hospital, No. 139 Huangong Road, Zibo 255400, 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