{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T21:34:23Z","timestamp":1793223263570,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Endocrinology"],"published-print":{"date-parts":[[2020,10,29]]},"abstract":"<jats:p>Background. The aim of this study was to compare the prevalence of low muscle mass and sarcopenia in patients with type 2 diabetes mellitus (T2DM) versus paired controls (control group, CG) and the association between sarcopenia and chronic diabetes complications. Methods. Men and women \u226550 years with T2DM (T2DM group, T2DMG) were recruited during routine outpatient visits. Total body densitometry and handgrip strength (HGS) were evaluated in the T2DMG and CG, while the T2DMG was also evaluated for the physical performance using the gait speed (GS) test. Sarcopenia was diagnosed according to the criteria of the Foundation for the National Institutes of Health Sarcopenia Project (FNIH). Results. The study included 177 individuals in the T2DMG and 146 in the CG. The mean HGS value was lower in the T2DMG (24.4\u2009\u00b1\u200910.3\u2009kg) compared with the CG (30.9\u2009\u00b1\u20099.15\u2009kg), <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>, with low HGS in 46 (25.9%) and 10 (9%) in the T2DMG and CG, respectively (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.001<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The prevalence of sarcopenia defined according to the FNIH criteria was higher in the T2DMG 23 (12.9%) compared with the CG 8 (5.4%), <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.03<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>. The presence of albuminuria increased the odds of sarcopenia (odds ratio (OR) 2.84, 95% confidence interval (CI) 1.07\u20137.68, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.04<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>) and osteoporosis (OR 3.38, 95% CI 1.12\u20139.89, <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>=<\/i:mo>\n                        <i:mn>0.03<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>), even in patients with mild to moderate nephropathy. The body composition analysis showed increased odds of sarcopenia with increased percentage of total fat (%TF) in women (OR 1.18, 95% CI, 1.03\u20131.43, <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.03<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>) and men (OR 1.31, 95% CI, 1.10\u20131.75, <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                        <m:mo>=<\/m:mo>\n                        <m:mn>0.01<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>). Conclusion. Patients with T2DM presenting with albuminuria, osteoporosis, and increased %TF were more likely to have sarcopenia. This finding emphasizes the need for patients with T2DM to be evaluated for sarcopenia to allow for early implementation of measures to prevent or treat this disorder.<\/jats:p>","DOI":"10.1155\/2020\/7841390","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T19:20:09Z","timestamp":1603999209000},"page":"1-9","source":"Crossref","is-referenced-by-count":42,"title":["Sarcopenia in Type 2 Diabetes Mellitus: A Cross-Sectional Observational Study"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2965-5268","authenticated-orcid":true,"given":"L. M.","family":"Pechmann","sequence":"first","affiliation":[{"name":"Internal Medicine and Endocrine Division (SEMPR), Universidade Federal do Paran\u00e1, Centro de Diabetes Curitiba, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1857-4737","authenticated-orcid":true,"given":"T. H.","family":"Jonasson","sequence":"additional","affiliation":[{"name":"Endocrine Division, Hospital de Cl\u00ednicas da Universidade Federal Do Paran\u00e1 (SEMPR), Avenida Agostinho Le\u00e3o J\u00fanior, 285, Alto da Gl\u00f3ria, Curitiba, PR 80030-110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7062-7085","authenticated-orcid":true,"given":"V. S.","family":"Canossa","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4879-587X","authenticated-orcid":true,"given":"H.","family":"Trierweiler","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Kisielewicz","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7735-1077","authenticated-orcid":true,"given":"R. R.","family":"Petterle","sequence":"additional","affiliation":[{"name":"Department of Integrative Medicine, Federal University of Paran\u00e1, Curitiba, PR, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9908-4907","authenticated-orcid":true,"given":"C. A.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Endocrine Division, Hospital de Cl\u00ednicas da Universidade Federal Do Paran\u00e1 (SEMPR), Avenida Agostinho Le\u00e3o J\u00fanior, 285, Alto da Gl\u00f3ria, Curitiba, PR 80030-110, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0555-0880","authenticated-orcid":true,"given":"V. Z. 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