{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:37:07Z","timestamp":1747190227148,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Respiratory Journal"],"published-print":{"date-parts":[[2020,7,6]]},"abstract":"<jats:p><jats:italic>Aims<\/jats:italic>. We investigated the histopathological features of solitary pulmonary necrotic nodules (NNs) of undetermined cause. We combined our findings with those obtained using other methods to determine how well the etiological factors were explained. <jats:italic>Methods<\/jats:italic>. We screened patients who underwent surgery to treat solitary pulmonary granulomatous and nongranulomatous NNs of undetermined cause. The NN sizes and features of both the NNs and adjacent parenchyma were evaluated. Histochemical analyses included Ehrlich\u2013Ziehl\u2013Neelsen (EZN), Grocott, and Gram staining. Polymerase chain reaction (PCR) was used to detect tuberculous and nontuberculous mycobacteria, panfungal DNA, <jats:italic>Nocardia<\/jats:italic>, <jats:italic>Francisella tularensis<\/jats:italic> types A and B, and actinomycetes. <jats:italic>Results<\/jats:italic>. The NNs were granulomatous in 78.9% and nongranulomatous in 21% of the 114 patients included. EZN staining or PCR was positive for <jats:italic>Mycobacterium<\/jats:italic> in 53.5% of all NNs: 62.2% of granulomatous and 20.8% of nongranulomatous NNs. We found a weak but significant correlation between granulomatous NNs and <jats:italic>Bacillus<\/jats:italic> positivity and a significant correlation between granulomas surrounding the NNs and the presence of multiple necroses. The NN etiology was determined via histopathological, histochemical, and PCR analyses in 57% of patients but remained undetermined in 42.9%. <jats:italic>Conclusion<\/jats:italic>. The causes of both granulomatous and nongranulomatous NNs can be determined by pathological examination. Granulomatous necrosis and granulomas in the adjacent parenchyma are important for differential diagnosis. When both features are present, they strongly support a diagnosis of tuberculosis, even in the absence of bacilli.<\/jats:p>","DOI":"10.1155\/2020\/7850750","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T23:31:34Z","timestamp":1594078294000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Benign Solitary Pulmonary Necrotic Nodules: How Effectively Does Pathological Examination Explain the Cause?"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0549-9969","authenticated-orcid":true,"given":"Halide Nur","family":"Urer","sequence":"first","affiliation":[{"name":"University of Health Sciences Turkey, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Pathology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Zeki","family":"Gunluoglu","sequence":"additional","affiliation":[{"name":"Medipol University School of Medicine, Thoracic Surgery, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurcan","family":"Unver","sequence":"additional","affiliation":[{"name":"University of Health Sciences Turkey, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Pathology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sezer","family":"Toprak","sequence":"additional","affiliation":[{"name":"University of Health Sciences Turkey, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Microbiology, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mediha Gonenc","family":"Ortakoylu","sequence":"additional","affiliation":[{"name":"University of Health Sciences Turkey, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Department of Pulmonary Medicine, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0012-2017"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jctube.2017.02.001"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2017.06.002"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2011-200336"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2113"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.062828"},{"issue":"1","key":"7","first-page":"108","volume":"88","year":"2005","journal-title":"Journal of the Medical Association of Thailand\u2009=\u2009Chotmaihet Thangphaet"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2013-0705-OA"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.5152\/balkanmedj.2012.061"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2017.06.003"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-010-0136-8"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2011.155"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.20"}],"container-title":["Canadian Respiratory Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2020\/7850750.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2020\/7850750.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crj\/2020\/7850750.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T23:31:36Z","timestamp":1594078296000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crj\/2020\/7850750\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,6]]},"references-count":13,"alternative-id":["7850750","7850750"],"URL":"https:\/\/doi.org\/10.1155\/2020\/7850750","relation":{},"ISSN":["1198-2241","1916-7245"],"issn-type":[{"type":"print","value":"1198-2241"},{"type":"electronic","value":"1916-7245"}],"subject":[],"published":{"date-parts":[[2020,7,6]]}}}