{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:00:23Z","timestamp":1783483223764,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Ophthalmology"],"published-print":{"date-parts":[[2020,1,17]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Glaucoma is a multifactorial optic neuropathy, which causes a continuous loss of retinal ganglion cells. Given the neurodegenerative nature of glaucoma, the necessity for neuroprotective intervention still arises, to be added alongside hypotonic therapy. <jats:italic>Objective<\/jats:italic>. The objective of this study was to assess the effect of daily intake of a homotaurine, carnosine, forskolin, vitamins B1, B2, and B6, folic acid, and magnesium based supplement (GANGLIOLIFE\u00ae) on the progression rates of the visual field in patients with progressive POAG despite good tonometric compensation and to assess the most suitable dosage. <jats:italic>Methods<\/jats:italic>. This is a monocentric nonrandomized experimental clinical study. Patients with mean deviation (MD) ranging from \u22122\u2009dB to \u221215\u2009dB with MD progression \u22651\u2009dB in the previous year and IOP values of \u226418\u2009mm Hg were included. All the patients underwent supplement therapy for a period of 6\u2009months. For the first 2\u2009months, they took 2 tablets a day, and for the following 4 months, 1 tablet a day. The patients were assessed before the start of treatment, time 0 (<jats:italic>T<\/jats:italic><jats:sub>0<\/jats:sub>), after 2 months (<jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub>), and after 6 months (<jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>) of therapy. At each check-up, patients were given a full eye test including perimetry, RNFL, and GCC using FD-OCT, PERG, contrast sensitivity, and QoL evaluation using the Glaucoma Symptom Scale questionnaire and National Eye Institute Visual Function Questionnaire 25. <jats:italic>Results<\/jats:italic>. 31 patients with a mean age of 70.80\u2009\u00b1\u20098.77 were included. At <jats:italic>T<\/jats:italic><jats:sub>1<\/jats:sub> and <jats:italic>T<\/jats:italic><jats:sub>2<\/jats:sub>, the mean values of MD were lessened (MD\u2009=\u2009\u22125.37\u2009\u00b1\u2009\u22122.91, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>, and MD\u2009=\u2009\u22125.48\u2009\u00b1\u20093.15, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>, respectively) compared to <jats:italic>T<\/jats:italic><jats:sub>0<\/jats:sub> (MD\u2009=\u2009-5.98\u2009\u00b1\u20092.83). Patients also demonstrated a significant reduction in IOP (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>), improved light sensitivity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.01<\/mml:mn><\/mml:mrow><\/mml:math>) and contrast sensitivity (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>), and a better quality of life (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>). <jats:italic>Conclusions<\/jats:italic>. Treatment with a supplement which includes homotaurine, carnosine, forskolin, vitamins B1, B2, and B6, folic acid, and magnesium has been shown to be able to slow down the rate of progression of functional damage and improve visual function after 2 and 6 months of daily intake. Quality of life showed significant improvement.<\/jats:p>","DOI":"10.1155\/2020\/7879436","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T18:33:50Z","timestamp":1579286030000},"page":"1-9","source":"Crossref","is-referenced-by-count":13,"title":["Assessing the Performance of Daily Intake of a Homotaurine, Carnosine, Forskolin, Vitamin B2, Vitamin B6, and Magnesium Based Food Supplement for the Maintenance of Visual Function in Patients with Primary Open Angle Glaucoma"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5825-0905","authenticated-orcid":true,"given":"Teresa","family":"Rolle","sequence":"first","affiliation":[{"name":"Eye Clinic, Department of Surgical Sciences, University of Torino, Torino, 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