{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:01:58Z","timestamp":1791824518906,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2020,1,7]]},"abstract":"<jats:p><jats:italic>Background.<\/jats:italic>The microbiome-derived trimethylamine-N-oxide (TMAO) and the intestinal permeability marker zonulin are considered to be linked with depression. Moreover, carbohydrate malabsorption (CMA) was shown to be associated with signs of depression. This study is aimed at investigating possible sex-specific associations between TMAO and zonulin and the presence of depressive signs in individuals with and without CMA.<jats:italic>Methods.<\/jats:italic>Serum concentrations of TMAO and zonulin were determined in 115 and 136 individuals with the presence or absence of CMA. All 251 study participants underwent lactase gene C\/T<jats:sub>-13910<\/jats:sub>polymorphism genotyping and fructose H<jats:sub>2<\/jats:sub>\/CH<jats:sub>4<\/jats:sub>breath testing. Additionally, they filled in the Beck Depression Inventory (BDI-II) questionnaire.<jats:italic>Results.<\/jats:italic>The median TMAO and zonulin serum concentrations were 2.66 (1.93\u20134.14)<jats:italic>\u03bc<\/jats:italic>mol\/L and 40.83 (34.73\u201347.48) ng\/mL. Serum TMAO levels were positively correlated with depressive symptoms (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.011<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>\u03c1<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.160<\/mml:mn><\/mml:math>). The strongest correlations were observed in 87 females (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.010<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>\u03c1<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.274<\/mml:mn><\/mml:math>) and 49 males (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.027<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mi>\u03c1<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.315<\/mml:mn><\/mml:math>) without CMA, whereas 115 patients with CMA showed no significant correlations. Zonulin tended to be negatively correlated with the BDI-II score in 49 males without CMA (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.062<\/mml:mn><\/mml:math>,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>\u03c1<\/mml:mi><mml:mrow><mml:mo>=<\/mml:mo><\/mml:mrow><mml:mrow><mml:mo>\u2212<\/mml:mo><\/mml:mrow><mml:mn>0.269<\/mml:mn><\/mml:math>).<jats:italic>Conclusion.<\/jats:italic>This study demonstrates a positive correlationship between the serum TMAO concentrations and the severity of depressive symptoms in females and males without CMA. Serum zonulin levels were negatively correlated with signs of depression in males without CMA. These findings suggest a gender-specific relationship between the serum TMAO and zonulin concentrations, depression, and CMA.<\/jats:p>","DOI":"10.1155\/2020\/7897240","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T23:31:22Z","timestamp":1578439882000},"page":"1-6","source":"Crossref","is-referenced-by-count":37,"title":["Sex-Specific Associations of Trimethylamine-N-Oxide and Zonulin with Signs of Depression in Carbohydrate Malabsorbers and Nonmalabsorbers"],"prefix":"10.1155","volume":"2020","author":[{"given":"Sophie","family":"Meinitzer","sequence":"first","affiliation":[{"name":"Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, 8036 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Baranyi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapeutic Medicine, Medical University of Graz, 8036 Graz, 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