{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:27:05Z","timestamp":1777480025113,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":341,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>The aim of this study is to reveal the certain human papillomavirus (HPV) genotype distribution between cervical cancer and esophageal cancer in the both high\u2010incidence geographic regions. For this study, we collected and detected the infection of HPV in 120 paraffin\u2010embedded esophageal tissues and 152 paraffin\u2010embedded cervical tissues, respectively. The esophageal tissues include 40 normal epithelium (ENOR), 26 dysplasia (DYS), and 54 invasive squamous cell carcinoma (ESCC). The cervical tissues consisted of 40 normal epithelium (CNOR), 53 intraepithelial neoplasia (CIN), and 59 invasive squamous cell carcinoma (CSCC). Both esophageal and cervical tissues collected in this study came from the same area, in which both the ESCC and CSCC were in high incidence, Xinjiang province, China. HPV GenoArray test kits were served to analyze the HPV infection. The result shows that among the 59 CSCC tissues, the total infection rate of HPV was 98.3% (58\/59). The positive rate of HPV\u201016 infection was 63.8% (37\/58). It indicated that HPV\u201016 is the most common infection among all of the high\u2010risk HPV. The multiple infection rate was 19.0% (11\/58). Among the 54 ESCC, a total of 7 genotypes were detected. The total infection rate of HPV was 61.1% (33\/54). The positive rate of HPV\u201016 infection was 63.6% (21\/33). The multiple infection rate was 6.1% (2\/33). Our result shows that high\u2010risk\u2010type HPV\u201016 was associated with both cervical cancer and esophageal cancer, which play a role in the high\u2010incidence area in Xinjiang. We hope that our results could point out the direction for the treatment strategy of HPV\u2010associated cancer, cervical cancer, and esophageal cancer and for the application of HPV vaccines in the future.<\/jats:p>","DOI":"10.1155\/2020\/7926754","type":"journal-article","created":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T19:10:22Z","timestamp":1607454622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Different Genotype Distribution of Human Papillomavirus between Cervical and Esophageal Cancers: A Study in Both High\u2010Incidence Areas, Xinjiang, China"],"prefix":"10.1155","volume":"2020","author":[{"given":"Yi","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yage","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8633-0892","authenticated-orcid":false,"given":"Limin","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,7]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X20132703"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30716"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2867-x"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29082"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_6_2","volume-title":"Human papillomavirus and related cancers, fact sheet 2018: China","author":"ICO\/IARC Information Centre (ES)","year":"2019"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26042"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-015-0531-8"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2009.01.004"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-011-9791-y"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1096-1"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2018.11.079"},{"key":"e_1_2_8_13_2","first-page":"405","article-title":"Detection of human papillomavirus DNA in cervical squamous cell carcinoma in Xinjiang Uygur women","volume":"32","author":"Lalai S. 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