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This paper introduces an upgraded version of the 2007 Zenker model for hemorrhagic shock termed the ZenCur model that allows for a better description of the time course of relevant observations. Our study provides a simple but realistic mathematical description of cardiovascular dynamics that may be useful in the assessment and prognosis of hemorrhagic shock. This model is capable of replicating the changes in mean arterial pressure, heart rate, and cardiac output after the onset of bleeding (as observed in four experimental laboratory animals) and achieves a reasonable compromise between an overly detailed depiction of relevant mechanisms, on the one hand, and model simplicity, on the other. The former would require considerable simulations and entail burdensome interpretations. From a clinical standpoint, the goals of the new model are to predict survival and optimize the timing of therapy, in both civilian and military scenarios.<\/jats:p>","DOI":"10.1155\/2020\/7936895","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T19:05:09Z","timestamp":1609182309000},"page":"1-21","source":"Crossref","is-referenced-by-count":4,"title":["A Simple Cardiovascular Model for the Study of Hemorrhagic Shock"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4571-1757","authenticated-orcid":true,"given":"Luciano","family":"Curcio","sequence":"first","affiliation":[{"name":"National Research Council of Italy, Institute for Biomedical Research and Innovation, Via Ugo La Malfa, 153, 90146 Palermo, Italy"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4899-9573","authenticated-orcid":true,"given":"Laura","family":"D\u2019Orsi","sequence":"additional","affiliation":[{"name":"National Research Council of Italy, Institute for Systems Analysis and Computer Science \u201cA. 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