{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:37:40Z","timestamp":1747190260039,"version":"3.40.5"},"reference-count":71,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Obesity"],"published-print":{"date-parts":[[2020,1,21]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Commercial weight loss programs provide valuable consumer options for those desiring support. Several commercial programs are reported to produce \u22653-fold greater weight loss than self-directed dieting. The effectiveness of JumpstartMD, a commercial pay-as-you-go program that emphasizes a low-to-very-low-carbohydrate real-food diet and optional pharmacologic treatment without prepackaged meals or meal replacement, has not previously been described. <jats:italic>Methods<\/jats:italic>. Completer and last observation carried forward (LOCF) of clinic-measured weight loss (kg) in 18,769 female and 3638 male JumpstartMD participants. <jats:italic>Results<\/jats:italic>. Completers lost (mean\u2009\u00b1\u2009SE) 8.7\u2009\u00b1\u20090.04\u2009kg, 9.5\u2009\u00b1\u20090.04% with 44.5\u2009\u00b1\u20090.5% achieving \u226510% weight loss at 3 months (mo, <jats:italic>N<\/jats:italic>\u2009=\u200914,999 completers); 11.8\u2009\u00b1\u20090.1\u2009kg, 12.6\u2009\u00b1\u20090.1% with 66.4\u2009\u00b1\u20090.6% achieving \u226510% weight loss at 6\u2009mo (<jats:italic>N<\/jats:italic>\u2009=\u200911,805); and 11.5\u2009\u00b1\u20090.2\u2009kg, 12.0\u2009\u00b1\u20090.2% with 57.6\u2009\u00b1\u20090.9% achieving \u226510% weight loss at 12\u2009mo (<jats:italic>N<\/jats:italic>\u2009=\u20098514). LOCF estimates were \u22126.5\u2009\u00b1\u20090.03\u2009kg, \u22127.2\u2009\u00b1\u20090.03% with 27.1\u2009\u00b1\u20090.3% achieving \u226510% weight loss at 3\u2009mo; \u22127.7\u2009\u00b1\u20090.04\u2009kg, \u22128.5\u2009\u00b1\u20090.04% with 36.3\u2009\u00b1\u20090.3% achieving \u226510% weight loss at 6\u2009mo; and \u22127.7\u2009\u00b1\u20090.1\u2009kg, \u22128.4\u2009\u00b1\u20090.1% with 34.6\u2009\u00b1\u20090.3% achieving \u226510% weight loss after 12\u2009mo. Frequent health coach meetings was a major determinant of weight loss, with women and men attending \u226575% of their weekly appointments losing 8.8\u2009\u00b1\u20090.04 and 11.9\u2009\u00b1\u20090.1\u2009kg, respectively, after 3\u2009mo, 13.1\u2009\u00b1\u20090.1 and 16.5\u2009\u00b1\u20090.3\u2009kg after 6\u2009mo, and 16.5\u2009\u00b1\u20090.3 and 19.4\u2009\u00b1\u20090.8\u2009kg after 12\u2009mo. Phentermine and phendimetrazine had a minor effect in women only at 1 (6.1% greater weight loss than untreated), 2 (4.1%), and 3\u2009mo (1.2%), but treated patients showed longer enrollment than nontreated during the first 3 (females: +0.4\u2009\u00b1\u20090.01; males: +0.3\u2009\u00b1\u20090.04\u2009mo), 6 (females: +1.1\u2009\u00b1\u20090.04; males: +1.0\u2009\u00b1\u20090.1\u2009mo), and 12\u2009mo (females: +2.7\u2009\u00b1\u20090.1; males: +2.4\u2009\u00b1\u20090.2\u2009mo). JumpstartMD produced generally greater weight loss than published reports for other real-food and prepackaged-meal commercial programs and somewhat greater or comparable losses to meal replacement diets. <jats:italic>Conclusion<\/jats:italic>. A one-on-one medically supervised program that emphasized real low-carbohydrate foods produced effective weight loss, particularly in those attending \u226575% of their weekly appointments.<\/jats:p>","DOI":"10.1155\/2020\/8026016","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T18:31:35Z","timestamp":1579631495000},"page":"1-24","source":"Crossref","is-referenced-by-count":0,"title":["Effect of JumpstartMD, a Commercial Low-Calorie Low-Carbohydrate Physician-Supervised Weight Loss Program, on 22,407 Adults"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4923-1849","authenticated-orcid":true,"given":"Sean","family":"Bourke","sequence":"first","affiliation":[{"name":"JumpstartMD, 350 Lorton Ave, Burlingame, CA 94010, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Maga\u00f1a","family":"Morton","sequence":"additional","affiliation":[{"name":"Department of Surgery, Stanford University 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