{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T22:19:48Z","timestamp":1785449988336,"version":"3.56.0"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":273,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Circular RNA (circRNA) is a noncoding RNA that forms a closed\u2010loop structure, and its abnormal expression may cause disease. We aimed to find potential network for circRNA\u2010related competitive endogenous RNA (ceRNA) in atrial fibrillation (AF). <jats:italic>Methods<\/jats:italic>. The circRNA, miRNA, and mRNA expression profiles in the heart tissue from AF patients were retrieved from the Gene Expression Omnibus database and analyzed comprehensively. Differentially expressed circRNAs (DEcircRNAs), differentially expressed miRNAs (DEmiRNAs), and differentially expressed mRNAs (DEmRNAs) were identified, followed by the establishment of DEcircRNA\u2010DEmiRNA\u2010DEmRNA regulatory network. Functional annotation analysis of host gene of DEcircRNAs and DEmRNAs in ceRNA regulatory network was performed. In vitro experiment and electronic validation were used to validate the expression of DEcircRNAs, DEmiRNAs, and DEmRNAs. <jats:italic>Results<\/jats:italic>. A total of 1611 DEcircRNAs, 51 DEmiRNAs, and 1250 DEmRNAs were identified in AF. The DEcircRNA\u2010DEmiRNA\u2010DEmRNA network contained 62 circRNAs, 14 miRNAs, and 728 mRNAs. Among which, two ceRNA regulatory pairs of hsa\u2010circRNA\u2010100053\u2010hsa\u2010miR\u2010455\u20105p\u2010TRPV1 and hsa\u2010circRNA\u2010005843\u2010hsa\u2010miR\u2010188\u20105p\u2010SPON1 were identified. In addition, six miRNA\u2010mRNA regulatory pairs including hsa\u2010miR\u201034c\u20105p\u2010INMT, hsa\u2010miR\u20101253\u2010DDIT4L, hsa\u2010miR\u2010508\u20105p\u2010SMOC2, hsa\u2010miR\u2010943\u2010ACTA1, hsa\u2010miR\u2010338\u20103p\u2010WIPI1, and hsa\u2010miR\u2010199a\u20103p\u2010RAP1GAP2 were also obtained. MTOR was a significantly enriched signaling pathway of host gene of DEcircRNAs. In addition, arrhythmogenic right ventricular cardiomyopathy, dilated cardiomyopathy, and hypertrophic cardiomyopathy were remarkably enriched signaling pathways of DEmRNAs in DEcircRNA\u2010DEmiRNA\u2010DEmRNA regulatory network. The expression validation of hsa\u2010circRNA\u2010402565, hsa\u2010miR\u201034c\u20105p, hsa\u2010miR\u2010188\u20105p, SPON1, DDIT4L, SMOC2, and WIPI1 was consistent with the integrated analysis. <jats:italic>Conclusion<\/jats:italic>. We speculated that hsa\u2010circRNA\u2010100053\u2010hsa\u2010miR\u2010455\u20105p\u2010TRPV1 and hsa\u2010circRNA\u2010005843\u2010hsa\u2010miR\u2010188\u20105p\u2010SPON1 interaction pairs may be involved in AF.<\/jats:p>","DOI":"10.1155\/2020\/8037273","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T17:35:26Z","timestamp":1601487326000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Identification of Circular RNA\u2010MicroRNA\u2010Messenger RNA Regulatory Network in Atrial Fibrillation by Integrated 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