{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:01:08Z","timestamp":1788908468958,"version":"build-2803163510"},"reference-count":80,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T00:00:00Z","timestamp":1587600000000},"content-version":"vor","delay-in-days":113,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. This systematic review and meta\u2010analysis was performed to determine the effectiveness of Omega\u20103 polyunsaturated fatty acid (<jats:italic>n<\/jats:italic>\u20103 PUFA) supplement on muscle soreness after eccentric exercise. <jats:italic>Methods<\/jats:italic>. PubMed, EMBASE, CENTRAL, and ISI Web of Science were searched to identify randomized controlled trials (RCTs) that assessed the efficacy of <jats:italic>n<\/jats:italic>\u20103 PUFA on muscle soreness after eccentric exercise. Mean difference (MD) and the associated 95% confidence interval (95% CI) were calculated by RevMan 5.3 to indicate delayed onset muscle soreness (DOMS) that measured two days after eccentric trainings. Subgroup analyses according to duration and daily dosage of <jats:italic>n<\/jats:italic>\u20103 PUFA supplements before eccentric exercises were performed to determine whether these factors will influence the overall effect size. The Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) approach was used to evaluate the certainty of evidence. The protocol of this systematic review and meta\u2010analysis was registered at PROSPERO (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42018085869\">CRD42018085869<\/jats:ext-link>). <jats:italic>Results<\/jats:italic>. 12 RCTs containing 145 subjects and 156 controls were included in this study. Meta\u2010analysis revealed a significantly decreased DOMS (MD \u20100.93; 95% CI \u20101.44, \u20100.42; <jats:italic>P<\/jats:italic> = 0.0004) in <jats:italic>n<\/jats:italic>\u20103 PUFA supplement groups, while no significant differences in isometric muscle strength and range of motion (ROM) were detected. However, the pooled effect size for DOMS was lower than the minimal clinically important difference (MCID) of 1.4 on the 10\u2010unit VAS, suggesting that the effect size of less muscle soreness with <jats:italic>n<\/jats:italic>\u20103 PUFA supplements did not appear to be clinically relevant. <jats:italic>Conclusion<\/jats:italic>. There is low\u2010quality evidence that <jats:italic>n<\/jats:italic>\u20103 PUFA supplementation does not result in a clinically important reduction of muscle soreness after eccentric exercise. Isometric muscle soreness and range of motion were not improved by <jats:italic>n<\/jats:italic>\u20103 PUFA supplementation either (low\u2010quality evidence). To further elucidate the overall role of <jats:italic>n<\/jats:italic>\u20103 PUFA on muscle damage in this area, large\u2010scale RCTs are still needed.<\/jats:p>","DOI":"10.1155\/2020\/8062017","type":"journal-article","created":{"date-parts":[[2020,4,23]],"date-time":"2020-04-23T23:35:32Z","timestamp":1587684932000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Omega\u20103 Polyunsaturated Fatty Acid Supplementation for Reducing Muscle Soreness after Eccentric Exercise: A Systematic Review and Meta\u2010Analysis of Randomized Controlled 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