{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:31:50Z","timestamp":1782484310651,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Obesity"],"published-print":{"date-parts":[[2020,2,10]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To analyze the ventilatory and alveolar-capillary diffusion dysfunctions in case of obesity with or without an OSAS.<jats:italic>Methods<\/jats:italic>. It is a cross-sectional study of 48 obese adults (23 OSAS and 25 controls). Anthropometric data (height, weight, and body mass index (BMI)) were collected. All adults responded to a medical questionnaire and underwent polysomnography or sleep polygraphy for apnea-hypopnea index (AHI) and percentage of desaturation measurements. The following lung function data were collected: pulmonary flows and volumes, lung transfer factor for carbon monoxide (DLCO), and fraction of exhaled nitric oxide (F<jats:sub>e<\/jats:sub>NO).<jats:italic>Results<\/jats:italic>. Obesity was confirmed for the two groups with a total sample mean value of BMI\u2009=\u200935.06\u2009\u00b1\u20094.68\u2009kg\/m<jats:sup>2<\/jats:sup>. A significant decrease in lung function was noted in patients with OSAS compared with controls. Indeed, when compared with the control group, the OSAS one had a severe restrictive ventilatory defect (total lung capacity: 93\u2009\u00b1\u200914 vs<jats:italic>.<\/jats:italic>79\u2009\u00b1\u200912%), an abnormal DLCO (112\u2009\u00b1\u200920 vs. 93\u2009\u00b1\u200922%), and higher bronchial inflammation (18.40\u2009\u00b1\u20099.20 vs<jats:italic>.<\/jats:italic>31.30\u2009\u00b1\u200913.60\u2009ppb) (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:mrow><\/mml:math>).<jats:italic>Conclusion<\/jats:italic>. Obesity when associated with OSAS increases the severity of pulmonary function and alveolar-capillary diffusion alteration. This can be explained in part by the alveolar inflammation.<\/jats:p>","DOI":"10.1155\/2020\/8075482","type":"journal-article","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T23:32:25Z","timestamp":1581377545000},"page":"1-6","source":"Crossref","is-referenced-by-count":13,"title":["The Ventilatory and Diffusion Dysfunctions in Obese Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1347-0100","authenticated-orcid":true,"given":"Sonia","family":"Rouatbi","sequence":"first","affiliation":[{"name":"Laboratory of Physiology and Explorations, Faculty of Medicine Sousse, University of Sousse, Sousse, Tunisia"},{"name":"Heart Failure (LR12SP09) Research Laboratory, Farhat Hached Hospital, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Ghannouchi","sequence":"additional","affiliation":[{"name":"Laboratory of Physiology and 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