{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:06:18Z","timestamp":1788206778867,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":63,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["20180520113JH"],"award-info":[{"award-number":["20180520113JH"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>The present study aimed to determine the pharmacokinetics and distribution of methylprednisolone sodium succinate (MPSS) and its metabolic product methylprednisolone (MP) in plasma and ocular tissues after periocular injection of MPSS in rabbit eyes. Forty\u2010eight healthy New Zealand white rabbits were randomly divided into 12 groups, including the control group and 11 MPSS\u2010treated groups sampling at different time points. Rabbits in the MPSS\u2010treated groups underwent left eye periocular injection of MPSS (10\u2009mg). The pharmacokinetics of MPSS and MP in plasma and ocular tissues (including aqueous humor, vitreous, iris, lens, sclera, optic nerve, and choroid and retina) were investigated by liquid chromatography tandem mass spectrometry (LC\u2010MS\/MS). After periocular injection, the time of maximum concentration (<jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub>) of MPSS ranged from 0.25\u2009h to 1\u2009h in ocular tissues and was 0.25\u2009h in plasma. <jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub> of MP in ocular tissues ranged from 0.5\u2009h to 6\u2009h, and <jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub> of MP in plasma was 0.5\u2009h. The maximum concentration (<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>) of MPSS and MP and the area under the curve (AUC<jats:sub>0-<jats:italic>t<\/jats:italic><\/jats:sub>) in ocular tissues from high to low was sclera, optic nerve, choroid and retina, iris, and lens. Especially, the concentrations of MPSS and MP in the lens were much lower when compared with the other ocular tissues. After periocular administration, MPSS could be rapidly metabolized to its active constituent MP in the ocular tissues. Also, the MPSS can be delivered effectively into the posterior segment of the eye (choroid and retina), while not easily be absorbed by the lens.<\/jats:p>","DOI":"10.1155\/2020\/8120398","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T23:32:28Z","timestamp":1583364748000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Pharmacokinetics after Periocular Methylprednisolone Sodium Succinate Injection in Rabbit Eyes"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5635-8525","authenticated-orcid":false,"given":"Hua-Yi","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5762-547X","authenticated-orcid":false,"given":"Xu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(50)91827-7"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2010.518522"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9394(01)00830-3"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1080\/09273940490883671"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1989.tb05366.x"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2008.11.009"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jms.2004"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2011.01.012"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200102000-00008"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/iae.0000000000000000"},{"key":"e_1_2_13_11_2","first-page":"1181","article-title":"Diffusion of high molecular weight compounds through sclera","volume":"41","author":"Ambati J.","year":"2000","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_13_12_2","first-page":"1186","article-title":"Transscleral delivery of bioactive protein to the choroid and retina","volume":"41","author":"Ambati J.","year":"2000","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(77)90136-1"},{"key":"e_1_2_13_14_2","first-page":"3054","article-title":"The effect of intraocular pressure on human and rabbit scleral permeability","volume":"40","author":"Rudnick D. 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