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Research shows that bioactive proteoglycans, e.g., versican and decorin, can actively trigger follicular phase shift by their anagen-inducing, anagen-maintaining, and immunoregulatory properties. This emerging insight has led to the recognition of \u201cdysregulated proteoglycan metabolism\u201d as a plausible causal or mediating pathology in hair growth disorders in both men and women. In support of this, declined expression of proteoglycans has been reported in cases of anagen shortening and follicular miniaturisation. To facilitate scientific communication, we propose designating this pathology \u201cfollicular hypoglycania (FHG),\u201d which results from an impaired ability of follicular cells to replenish and maintain a minimum relative concentration of key proteoglycans during anagen. Lasting FHG may advance to structural decay, called proteoglycan follicular atrophy (PFA). This process is suggested to be an integral pathogenetic factor in pattern hair loss (PHL) and telogen effluvium (TE). To address FHG and PFA, a proteoglycan replacement therapy (PRT) program using oral administration of a marine-derived extract (Nourkrin\u00ae with Marilex\u00ae, produced by Pharma Medico Aps, Aarhus, Denmark) containing specific proteoglycans has been developed. In clinical studies, this treatment significantly reduced hair fall, promoted hair growth, and improved quality of life in patients with male- and female-pattern hair loss. Accordingly, PRT (using Nourkrin\u00ae with Marilex\u00ae) can be recommended as an add-on treatment or monotherapy in patients with PHL and TE.<\/jats:p>","DOI":"10.1155\/2020\/8125081","type":"journal-article","created":{"date-parts":[[2020,5,5]],"date-time":"2020-05-05T23:52:11Z","timestamp":1588722731000},"page":"1-17","source":"Crossref","is-referenced-by-count":21,"title":["Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin\u00ae with Marilex\u00ae in Pattern Hair Loss and Telogen Effluvium"],"prefix":"10.1155","volume":"2020","author":[{"given":"Jan","family":"Wadstein","sequence":"first","affiliation":[{"name":"Research and Development, Wadlund A\/S, Lund, 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