{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T16:01:35Z","timestamp":1740153695361,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/09550-4"],"award-info":[{"award-number":["2017\/09550-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Dentistry"],"published-print":{"date-parts":[[2020,3,26]]},"abstract":"<jats:p>The multimodal approach for patients with head and neck cancer (HNC) includes treatment with chemoradiation therapy (CRT). A common concern regarding CRT side effects is the occurrence of structural and physiological alterations of the salivary glands due to exposure to ionizing radiation. The aim of this study is to examine the morphology, volume, and density of the parotid glands before and after CRT in HNC patients. A total of 49 HNC patients treated exclusively with CRT were included in the study. Ninety-eight parotid glands were evaluated before and after treatment by using contrast-enhanced computed tomography (CECT). Shapiro\u2013Wilk test was performed, and the variables (pre-CRT and post-CRT) presented normal distribution. Pearson\u2019s coefficient was used to assess the correlation between volume and density. CRT resulted in a significant decrease in the mean volume of the parotid glands (i.e., original volume reduced by 20.5%; <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.0001<\/mml:mn><\/mml:mrow><\/mml:math>). CRT induced a 30.0% (7 Hounsfield units) increase in density of the right parotid gland and a 24.9% (8 Hounsfield units) increase in density of the left parotid gland (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0198<\/mml:mn><\/mml:mrow><\/mml:math> and <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.0079<\/mml:mn><\/mml:mrow><\/mml:math>, respectively). Changes in morphology and spatial configuration, increased density, and substantial loss of volume of the parotid glands were observed after CRT. There was also a difference in density (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.003<\/mml:mn><\/mml:mrow><\/mml:math>) in the right-side parotid glands in comparison between xerostomic and nonxerostomic groups of patients. These facts lead to the need for a personalized CRT planning in order to minimize oral complications related to the treatment.<\/jats:p>","DOI":"10.1155\/2020\/8176260","type":"journal-article","created":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T23:31:25Z","timestamp":1585265485000},"page":"1-9","source":"Crossref","is-referenced-by-count":1,"title":["Morphology, Volume, and Density Characteristics of the Parotid Glands before and after Chemoradiation Therapy in Patients with Head and Neck Tumors"],"prefix":"10.1155","volume":"2020","author":[{"given":"Wellington Pereira dos","family":"Santos","sequence":"first","affiliation":[{"name":"Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Pedro","family":"Perez Gomes","sequence":"additional","affiliation":[{"name":"Department of Stomatology, School of Dentistry, University of Sa\u0303o Paulo (USP), Sa\u0303o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Drumstas","family":"Nussi","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry, Cruzeiro do Sul University (UNICSUL), Sa\u0303o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Joa\u0303o Mauricio Altemani","sequence":"additional","affiliation":[{"name":"Department of Radiology, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Botti Rodrigues dos Santos","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry, Cruzeiro do Sul University (UNICSUL), Sa\u0303o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt","family":"Hasseus","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Pathology, Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1349-9336","authenticated-orcid":true,"given":"Daniel","family":"Giglio","sequence":"additional","affiliation":[{"name":"Department of Oncology, Institute of Clinical Sciences, University of Gothenburg Sahlgrenska Academy, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1842-9521","authenticated-orcid":true,"given":"Paulo Henrique","family":"Braz-Silva","sequence":"additional","affiliation":[{"name":"Department of Stomatology, School of Dentistry, University of Sa\u0303o Paulo (USP), Sa\u0303o Paulo, SP, Brazil"},{"name":"Laboratory of Virology, Institute of Tropical Medicine of S\u00e3o Paulo, School of Medicine, University of S\u00e3o Paulo (USP), S\u00e3o Paulo, SP, 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