{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:38:13Z","timestamp":1747190293525,"version":"3.40.5"},"reference-count":65,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Medical University of Nis","award":["45","\u041e-07-17","\u041e-06-17","41018","31060","43012"],"award-info":[{"award-number":["45","\u041e-07-17","\u041e-06-17","41018","31060","43012"]}]},{"name":"Serbian Academy of Sciences and Arts","award":["45","\u041e-07-17","\u041e-06-17","41018","31060","43012"],"award-info":[{"award-number":["45","\u041e-07-17","\u041e-06-17","41018","31060","43012"]}]},{"name":"Serbian Academy of Sciences and Arts","award":["45","\u041e-07-17","\u041e-06-17","41018","31060","43012"],"award-info":[{"award-number":["45","\u041e-07-17","\u041e-06-17","41018","31060","43012"]}]},{"name":"Ministry of Science and Technological Development, Republic of Serbia","award":["45","\u041e-07-17","\u041e-06-17","41018","31060","43012"],"award-info":[{"award-number":["45","\u041e-07-17","\u041e-06-17","41018","31060","43012"]}]},{"name":"Ministry of Science and Technological Development, Republic of Serbia","award":["45","\u041e-07-17","\u041e-06-17","41018","31060","43012"],"award-info":[{"award-number":["45","\u041e-07-17","\u041e-06-17","41018","31060","43012"]}]},{"name":"Ministry of Science and Technological Development, Republic of Serbia","award":["45","\u041e-07-17","\u041e-06-17","41018","31060","43012"],"award-info":[{"award-number":["45","\u041e-07-17","\u041e-06-17","41018","31060","43012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2020,8,18]]},"abstract":"<jats:p>Balkan endemic nephropathy (BEN) represents a chronic tubulointerstitial nephropathy which is followed by the progression of kidney fibrosis to end-stage kidney failure. The critical involvement of poisons in food (aristolochic acid (AA), ochratoxin, and heavy metals) and selenium deficiency are among nutritive factors which contribute to the pathogenesis of BEN, due to reactive oxygen species (ROS) liberation and\/or decreased antioxidative defence system. The aim of the study is to distinguish a possible systemic and local origin of ROS through the measurement of xanthine oxidase (XO) activity in urine and plasma, along with the determination of the oxidative changes in lipids and proteins. The study included 50 patients with BEN and 38 control healthy subjects. We noted increased levels of both thiobarbituric acid-reactive substances (TBARS) and advanced oxidation protein products (AOPPs) in the plasma of patients with BEN, compared to the control group (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). The urinary levels of AOPPs were higher in patients with BEN in comparison to the control (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>). The specific activity of XO was significantly lower in plasma and urine in BEN samples, compared to controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.005<\/mml:mn><\/mml:math>). Based on these results, we hypothesize that XO might not be considered a direct systemic or local contributor to ROS production in BEN, most probably because of the diminished kidney functional tissue mass and\/or AA-induced changes in purine nucleotide conformation. The increased AOPP and TBARS level in both plasma and urine in BEN may predict ROS systemic liberation with toxic local effects.<\/jats:p>","DOI":"10.1155\/2020\/8209727","type":"journal-article","created":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:13:09Z","timestamp":1597795989000},"page":"1-8","source":"Crossref","is-referenced-by-count":3,"title":["Local and Systemic Oxidative Stress in Balkan Endemic Nephropathy Is Not Associated with Xanthine Oxidase Activity"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5950-7517","authenticated-orcid":true,"given":"Andrej","family":"Veljkovi\u0107","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovan","family":"Had\u017ei- \u0110oki\u0107","sequence":"additional","affiliation":[{"name":"Serbian Academy of Sciences and Arts, 11000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Du\u0161an","family":"Sokolovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rade","family":"\u010cukuranovi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Center in Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jovana","family":"\u010cukuranovi\u0107-Kokoris","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragoslav","family":"Ba\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Clinical Center in Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4521-1253","authenticated-orcid":true,"given":"Branka","family":"\u0110or\u0111evi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Stojanovi\u0107","sequence":"additional","affiliation":[{"name":"Clinical Center in Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrija","family":"\u0160melcerovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordana","family":"Koci\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Nis, 18000 Nis, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00508-005-0426-8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020297"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro1019"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/920723"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2006.11.019"},{"key":"6","first-page":"14","volume":"7","year":"1956","journal-title":"Savremenna Medicina"},{"key":"7","first-page":"2039","volume":"65","year":"1957","journal-title":"La Presse M\u00e9dicale"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/em.21756"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sft049"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2008.09.002"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft384"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21031157"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/risa.12239"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.5414\/cnp83s064"},{"volume":"34, article e8547","journal-title":"Rapid Communications in Mass Spectrometry","year":"2019","key":"15"},{"key":"16","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1093\/carcin\/bgu095","volume":"35","year":"2014","journal-title":"Carcinogenesis"},{"key":"17","first-page":"57","volume":"32","year":"2010","journal-title":"Neuroendocrinology Letters"},{"key":"18","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.3390\/ijms18102144","volume":"18","year":"2017","journal-title":"International Journal of Molecular Sciences"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008111133"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/11.2.313"},{"issue":"1","key":"21","first-page":"81","volume":"59","year":"2020","journal-title":"Journal of Food and Nutrition Research"},{"key":"22","first-page":"12","volume":"34","year":"1991","journal-title":"Kidney International. Supplement"},{"issue":"2-3","key":"23","first-page":"300","volume":"10","year":"1997","journal-title":"Biomedical and Environmental Sciences"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1007\/BF02784022"},{"key":"25","first-page":"2","volume":"7","year":"2020","journal-title":"Environments"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000231"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12745"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00969.x"},{"key":"29","first-page":"111","volume":"45","year":"1994","journal-title":"Kidney International"},{"key":"30","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.plipres.2003.10.001","volume":"43","year":"2004","journal-title":"Progress in Lipid Research"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00232-X"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.186"},{"issue":"6","key":"33","first-page":"597","volume":"51","year":"2002","journal-title":"Physiological Research"},{"key":"34","first-page":"31","volume":"1","year":"2017","journal-title":"Journal of Clinical & Experimental Nephrology"},{"key":"35","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000213081","volume":"112","year":"2009","journal-title":"Nephron. Clinical Practice"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2011.01.016"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.3109\/0886022x.2014.882240"},{"key":"38","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.foodchem.2011.11.070","volume":"132","year":"2012","journal-title":"Food Chemistry"},{"key":"39","first-page":"1273","volume":"91","year":"1969","journal-title":"Lije\u010d Vjesn"},{"issue":"10","key":"40","first-page":"1038","volume":"11","year":"2020","journal-title":"Cell Death & Disease"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2012.723661"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1113\/EP085333"},{"issue":"6","key":"43","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2903\/j.efsa.2006.365","volume":"4","year":"2006","journal-title":"The EFSA Journal"},{"key":"44","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.clnu.2004.12.001","volume":"24","year":"2005","journal-title":"Clinical Nutrition"},{"key":"45","first-page":"11","volume":"10","year":"2020","journal-title":"Biomolecules"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006070781"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2003.00044.x"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092532"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2008.05.002"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2011.05.052"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3182241106"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-011-0610-5"},{"key":"53","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1152\/ajprenal.00104.2008","volume":"295","year":"2008","journal-title":"American Journal of Physiology-Renal Physiology"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.1111\/sdi.12818"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3081856"},{"key":"56","first-page":"389","volume":"9","year":"1994","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"57","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1177\/0960327120905957","volume":"39","year":"2020","journal-title":"Human & Experimental Toxicology"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112283"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-016-1288-2"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081911"},{"key":"61","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1093\/ndt\/gft029","volume":"28","year":"2013","journal-title":"Nephrology Dialysis Transplantation"},{"key":"62","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000034910.58454.FD"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2016.6665"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a124480"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv701"}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/8209727.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/8209727.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2020\/8209727.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:13:37Z","timestamp":1597796017000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/omcl\/2020\/8209727\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,18]]},"references-count":65,"alternative-id":["8209727","8209727"],"URL":"https:\/\/doi.org\/10.1155\/2020\/8209727","relation":{},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"type":"print","value":"1942-0900"},{"type":"electronic","value":"1942-0994"}],"subject":[],"published":{"date-parts":[[2020,8,18]]}}}