{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T09:29:31Z","timestamp":1785403771730,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T00:00:00Z","timestamp":1594684800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011615","name":"University of Ruhuna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scientifica"],"published-print":{"date-parts":[[2020,7,14]]},"abstract":"<jats:p>Methicillin-resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MRSA) is a major cause of hospital- and community-acquired infections worldwide. Therefore, this study was conducted to explore the antibacterial activity of the two medicinal plants <jats:italic>Epaltes divaricata<\/jats:italic> and <jats:italic>Vetiveria zizanioides<\/jats:italic> against strains of MRSA which were isolated from patients with skin and soft tissue infections. Hexane, ethanol, and water extracts of <jats:italic>E. divaricata<\/jats:italic> (whole plant) and <jats:italic>V. zizanioides<\/jats:italic> (roots) were prepared. Clinical isolates of MRSA strains (<jats:italic>n<\/jats:italic>\u2009=\u200920) were used for the study. Bacterial susceptibility was tested using a disc diffusion assay. Minimum inhibitory concentration (MIC) was determined by a broth microdilution method. Vancomycin was used as the positive control. Hexane, ethanol, and water extracts of <jats:italic>E. divaricata<\/jats:italic> showed inhibitory zones against MRSA. Except for water extract, both hexane and ethanol extracts of <jats:italic>V. zizanioides<\/jats:italic> showed inhibitory zones. MIC ranges of hexane, ethanol, and water extracts in <jats:italic>E. divaricata<\/jats:italic> were 0.012\u20130.32\u2009mg\/mL, 0.019\u20132.4\u2009mg\/mL, and 0.019\u20130.48\u2009mg\/mL, respectively. Respective MIC ranges of hexane and ethanol extracts of <jats:italic>V. zizanioides<\/jats:italic> were 0.003\u20130.032\u2009mg\/mL and 0.019\u20132.4\u2009mg\/mL. The hexane extract of <jats:italic>V. zizanioides<\/jats:italic> inhibited 55% of the selected MRSA strains at a relatively low MIC value of 0.012\u2009mg\/mL. The hexane extract of both plants demonstrated inhibition of 75% of MRSA strains at a MIC value of 0.064\u2009mg\/mL. Ethanol extract of <jats:italic>V. zizanioides<\/jats:italic> and <jats:italic>E. divaricata,<\/jats:italic> respectively, inhibited 70% and 45% of MRSA strains at the MIC of 0.096\u2009mg\/mL, whereas water extract of <jats:italic>E. divaricata<\/jats:italic> inhibited 80% of MRSA strains at the same MIC. Both <jats:italic>E. divaricata<\/jats:italic> and <jats:italic>V. zizanioides<\/jats:italic> were equally effective against MRSA at a MIC of 0.064\u2009mg\/mL. But <jats:italic>V. zizanioides<\/jats:italic> was more effective since the hexane extract inhibited more than 50% of MRSA strains at significantly a lower MIC value of 0.012\u2009mg\/mL. Fractionation, purification, and identification of active compounds will warrant further evaluation of the therapeutic potential of both plant extracts.<\/jats:p>","DOI":"10.1155\/2020\/8239053","type":"journal-article","created":{"date-parts":[[2020,7,14]],"date-time":"2020-07-14T23:33:30Z","timestamp":1594769610000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of <i>In Vitro<\/i> Antibacterial Activity of <i>Epaltes divaricata<\/i> and <i>Vetiveria zizanioides<\/i> against Methicillin-Resistant <i>Staphylococcus aureus<\/i>"],"prefix":"10.1155","volume":"2020","author":[{"given":"Hasanga","family":"Rathnayake","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Matara, Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manikkuwadura Hasara Nethmini","family":"De Zoysa","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Science, 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