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Paravalvular leak (PVL) is common after transcatheter aortic valve implantation (TAVI) and has been linked with worse survival. This study aimed to investigate the determinants and outcome of PVL after TAVI and determine the role of aortic valve calcification (AVC) distribution in predicting PVL. <jats:italic>Methods and Results<\/jats:italic>. This was a retrospective cohort study of 270 consecutive patients who underwent TAVI. Determinants and outcomes of \u2265mild PVL were assessed. Matching rates of PVL jet with AVC distribution were calculated. AVC volume, larger annulus dimensions, and transvalvular peak velocity were risk factors for \u2265mild PVL after TAVI. AVC volume was an independent predictor of \u2265mild PVL. On the other hand, annulus ellipticity, left ventricular outflow tract nontubularity, and diameter-derived prosthesis mismatch were not found to predict PVL after TAVI. PVL jet matched, in varying proportions, with calcification at all aortic root regions, and the highest matching rate was with calcifications at body of leaflets. Moreover, matching rates were less with commissure compared to cusp calcifications. Mild or greater PVL was not associated with all-cause and cardiovascular mortality up to 1-year follow-up. <jats:italic>Conclusion<\/jats:italic>. \u2265mild PVL after TAVI is common and can be predicted by aortic root calcification volume, larger annulus dimensions, and pre-TAVI transvalvular peak velocity, with calcification volume being an independent predictor for PVL. However, annulus ellipticity, left ventricular outflow tract nontubularity, and diameter-derived prosthesis mismatch had no role in predicting PVL. Importantly, body of leaflet calcifications (versus annulus and tip of leaflet) and cusp calcifications (versus commissure calcification) are more important in predicting PVL. No association between \u2265mild PVL and increased risk of all-cause and cardiovascular mortality at 1-year follow-up.<\/jats:p>","DOI":"10.1155\/2020\/8249497","type":"journal-article","created":{"date-parts":[[2020,5,22]],"date-time":"2020-05-22T23:48:52Z","timestamp":1590191332000},"page":"1-11","source":"Crossref","is-referenced-by-count":37,"title":["Incidence, Predictors, and Outcome of Paravalvular Leak after Transcatheter Aortic Valve Implantation"],"prefix":"10.1155","volume":"2020","author":[{"given":"Abdullah","family":"Hagar","sequence":"first","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, Sichuan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu 610041, Sichuan, 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