{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T20:36:39Z","timestamp":1757450199306,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T00:00:00Z","timestamp":1586736000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2020,4,13]]},"abstract":"<jats:p>Portal vein thrombosis is a major complication associated with liver cirrhosis. In cirrhotic patients, a decrease in procoagulant and anticoagulant factors and an unstable balance between them is observed, and a relative decrease in the activation of anticoagulant drivers is one of the main causes of portal vein thrombosis (PVT). Herein, we report a case of acute portal thrombosis associated with liver cirrhosis and treated with a recombinant form of soluble thrombomodulin (thrombomodulin alpha, TM-<jats:italic>\u03b1<\/jats:italic>) in combination with antithrombin III. TM-<jats:italic>\u03b1<\/jats:italic> was administered in accordance with the dosage and route of administration for disseminated intravascular coagulation therapy and resulted in dissolution of PVT with a gradual decrease in D-dimer levels. No adverse events were observed during the course of treatment. In the future, in addition to conventional anticoagulation therapy using heparin or antivitamin K drugs, novel therapies targeting protein C activation using a recombinant form of soluble thrombomodulin may play an important role in the treatment of acute PVT.<\/jats:p>","DOI":"10.1155\/2020\/8268016","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T23:32:10Z","timestamp":1586820730000},"page":"1-4","source":"Crossref","is-referenced-by-count":2,"title":["Acute Portal Vein Thrombosis Treated with Recombinant Human Soluble Thrombomodulin Combined with Antithrombin III"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1861-1961","authenticated-orcid":true,"given":"Satoshi","family":"Nakayama","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Mishuku Hospital, 5-33-12, Kamimeguro, Meguro-ku, Tokyo 153-0051, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoya","family":"Murashima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Mishuku Hospital, 5-33-12, Kamimeguro, Meguro-ku, Tokyo 153-0051, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(85)90327-0"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.042796"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2009.08.003"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.05.023"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.05921.x"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2012.02839.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2147\/vhrm.1.1.41.58936"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v75.2.329.329"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02267.x"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/1477-9560-11-3"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2014.12.002"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.03.027"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.12934"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1011170"},{"issue":"264","key":"15","first-page":"4743","volume":"264","year":"1989","journal-title":"The Journal of Biological Chemistry"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v59.5.1067.1067"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13087"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2015.08.002"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i2.533"},{"key":"20","first-page":"347","volume":"34","year":"2006","journal-title":"Japanese Pharmacology & Therapeitics"}],"container-title":["Case Reports in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2020\/8268016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2020\/8268016.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crim\/2020\/8268016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T23:32:11Z","timestamp":1586820731000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crim\/2020\/8268016\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,13]]},"references-count":20,"alternative-id":["8268016","8268016"],"URL":"https:\/\/doi.org\/10.1155\/2020\/8268016","relation":{},"ISSN":["1687-9627","1687-9635"],"issn-type":[{"type":"print","value":"1687-9627"},{"type":"electronic","value":"1687-9635"}],"subject":[],"published":{"date-parts":[[2020,4,13]]}}}