{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:06:06Z","timestamp":1762376766943,"version":"3.41.2"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T00:00:00Z","timestamp":1594252800000},"content-version":"vor","delay-in-days":190,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571883"],"award-info":[{"award-number":["81571883"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p>External ventricular drainage (EVD) is widely used in patients with a traumatic brain injury (TBI). However, the EVD weaning trial protocol varies and insufficient studies focus on the intracranial pressure (ICP) during the weaning trial. We aimed to establish the relationship between ICP during an EVD weaning trial and the outcomes of TBI. We enrolled 37 patients with a TBI with an EVD from July 2018 to September 2019. Among them, 26 were allocated to the favorable outcome group and 11 to the unfavorable outcome group (death, post\u2010traumatic hydrocephalus, persistent vegetative state, and severe disability). Groups were well matched for sex, pupil reactivity, admission Glasgow Coma Scale score, Marshall computed tomography score, modified Fisher score, intraventricular hemorrhage, EVD days, cerebrospinal fluid output before the weaning trial, and the complications. Before and during the weaning trial, we recorded the ICP at 1\u2010hour intervals to calculate the mean ICP, delta ICP, and ICP burden, which was defined as the area under the ICP curve. There were significant between\u2010group differences in the age, surgery types, and intensive care unit days (<jats:italic>p<\/jats:italic> = 0.045, <jats:italic>p<\/jats:italic> = 0.028, and <jats:italic>p<\/jats:italic> = 0.004, respectively). During the weaning trial, 28 (75.7%) patients had an increased ICP. Although there was no significant difference in the mean ICP before and during the weaning trial, the delta ICP was higher in the unfavorable outcome group (<jats:italic>p<\/jats:italic> = 0.001). Moreover, patients who experienced death and hydrocephalus had a higher ICP burden, which was above 20\u2009mmHg (<jats:italic>p<\/jats:italic> = 0.016). Receiver operating characteristic analyses demonstrated the predictive ability of these variables (area under the curve [AUC] = 0.818 [<jats:italic>p<\/jats:italic> = 0.002] for delta ICP and AUC = 0.758 [<jats:italic>p<\/jats:italic> = 0.038] for ICP\u2009burden &gt; 20\u2009mmHg). ICP elevation is common during EVD weaning trials in patients with TBI. ICP\u2010related parameters, including delta ICP and ICP burden, are significant outcome predictors. There is a need for larger prospective studies to further explore the relationship between ICP during EVD weaning trials and TBI outcomes.<\/jats:p>","DOI":"10.1155\/2020\/8379134","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T23:56:09Z","timestamp":1594338969000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intracranial Pressure during External Ventricular Drainage Weaning Is an Outcome Predictor of Traumatic Brain 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