{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:56:15Z","timestamp":1761897375064,"version":"3.41.2"},"reference-count":120,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:00:00Z","timestamp":1604880000000},"content-version":"vor","delay-in-days":313,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673412"],"award-info":[{"award-number":["81673412"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Since December 2019, coronavirus disease 2019 (COVID\u201019) due to SARS\u2010CoV\u20102 infection has emerged in Wuhan and rapidly spread throughout China and even to other countries. Combined therapy with modern medicine and traditional Chinese medicine has been proposed, in which <jats:italic>Shen Zhu San<\/jats:italic> (SZS) was regarded as one of the basic prescriptions. <jats:italic>Methods<\/jats:italic>. Network pharmacological approaches along with candidate compound screening, target prediction, target tissue location, protein\u2010protein interaction network, gene ontology (GO), KEGG enrichment analyses, and gene microarray analyses were applied. <jats:italic>Results<\/jats:italic>. A total of 627 targets of the 116 active ingredients of SZS were identified. Targets in immune cells and tissues were much more abundant than those in other tissues. A total of 597 targets were enriched in the GO biological cellular process, while 153 signaling pathways were enriched according to the KEGG analysis. A total of 450 SARS\u2010related targets were integrated and intersected with the targets of SZS to identify 40 common targets that were significantly enriched in five immune function aspects of the immune system process during GO analysis. Several inflammation\u2010related pathways were found to be significantly enriched throughout the study. <jats:italic>Conclusions<\/jats:italic>. The therapeutic mechanisms of the effects of SZS on COVID\u201019 potentially involve four effects: suppressing cytokine storms, protecting the pulmonary alveolar\u2010capillary barrier, regulating the immune response, and mediating cell death and survival.<\/jats:p>","DOI":"10.1155\/2020\/8468303","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T18:20:48Z","timestamp":1604946048000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Investigation of the Potential Mechanism Governing the Effect of the <i>Shen Zhu San<\/i> on COVID\u201019 by Network Pharmacology"],"prefix":"10.1155","volume":"2020","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1028-2980","authenticated-orcid":false,"given":"Yuxuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2462-047X","authenticated-orcid":false,"given":"Yuhua","family":"Ru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8907-9453","authenticated-orcid":false,"given":"Guowei","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0315-3670","authenticated-orcid":false,"given":"Maozheng","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0448-7832","authenticated-orcid":false,"given":"Shuangqiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1152-1050","authenticated-orcid":false,"given":"Jiarui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1018-1936","authenticated-orcid":false,"given":"Chongyi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5595-2082","authenticated-orcid":false,"given":"Xiaohe","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0978-5743","authenticated-orcid":false,"given":"Yanqi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6449-4914","authenticated-orcid":false,"given":"Ya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4334-2038","authenticated-orcid":false,"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6769-3647","authenticated-orcid":false,"given":"Zhigang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5126-9788","authenticated-orcid":false,"given":"Depei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6701-8825","authenticated-orcid":false,"given":"Minghua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,9]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)30183-5"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)30300-7"},{"key":"e_1_2_11_3_2","unstructured":"The State Council Information Office PRC SCIO briefing on the joint response to the new coronavirus-related pneumonia outbreak 2020 http:\/\/english.scio.gov.cn\/pressroom\/2020-01\/29\/content_75657018.htm."},{"key":"e_1_2_11_4_2","unstructured":"World Health Organization WHO director-general\u2019s statement on ihr emergency committee on novel coronavirus (2019-nCoV) 2020 https:\/\/www.who.int\/dg\/speeches\/detail\/who-director-general-s-statement-on-ihr-emergency-committee-on-novel-coronavirus-(2019-ncov)."},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.02.027"},{"volume-title":"Severe Acute Respiratory Syndrome-Related Coronavirus: the Species and its Viruses, a Statement of the Coronavirus Study Group","year":"2020","author":"Gorbalenya A.","key":"e_1_2_11_6_2"},{"key":"e_1_2_11_7_2","unstructured":"Global Biodefense WHO names disease caused by new coronavirus: COVID-19. 2020 https:\/\/globalbiodefense.com\/2020\/02\/11\/who-names-disease-caused-by-new-coronavirus-covid-19\/."},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-020-03899-4"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(20)30251-8"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-020-0688-y"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/v12030254"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001316"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30211-7"},{"key":"e_1_2_11_15_2","article-title":"Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in wuhan, China","volume":"395","author":"Wang D.","year":"2020","journal-title":"JAMA"},{"key":"e_1_2_11_16_2","article-title":"Interpretation of guidelines for the diagnosis and treatment of novel coronavirus (2019-nCoV) infection by the National Health Commission (trial version 5)","volume":"100","author":"Lin L.","year":"2020","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_11_17_2","first-page":"281","article-title":"XinXing GuanZhuangBingDu (2019-nCoV) FeiYan ZhongYi LinChuangTeZheng yu BianZhengZhiLiao ChuTan","volume":"4","author":"Wang Y. G.","year":"2020","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"e_1_2_11_18_2","first-page":"277","article-title":"ZhongYiYao FangZhi XinXing GuanZhuangBingDuGanRan de FeiYan GeDi ZhenLiao FangAn ZongHe FenXi","volume":"4","author":"Zheng W. K.","year":"2020","journal-title":"Journal of Traditional Chinese Medicine"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.19852\/j.cnki.jtcm.2020.03.019"},{"volume-title":"Zhongyi Fangji Dacidian","year":"1996","author":"Peng H.","key":"e_1_2_11_20_2"},{"key":"e_1_2_11_21_2","first-page":"40","volume-title":"Pharmacopoeia of the People\u2019s Republic of China 2020 Edition","author":"Chinese Pharmacopoeia Commission","year":"2020"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2006.06.002"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.03.022"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.02.050"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v14i3.26"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.1080\/01480540902873837"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5929234"},{"key":"e_1_2_11_28_2","first-page":"625","article-title":"Research advancement on pharmacological effect of radix Angelicae Dahuricae","volume":"20","author":"Wu Y.","year":"2009","journal-title":"Lishizhen Medicine and Materia Medica Research (In Chinese)"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1527-3466.2005.tb00157.x"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.81"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.109664"},{"key":"e_1_2_11_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1104"},{"key":"e_1_2_11_33_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5194016"},{"key":"e_1_2_11_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131"},{"key":"e_1_2_11_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"volume-title":"A Familial Cluster of Pneumonia Associated with the 2019 Novel Coronavirus Indicating Person-To-Person Transmission: A Study of a Family Cluster","year":"2020","author":"Chan J. F. W.","key":"e_1_2_11_36_2"},{"key":"e_1_2_11_37_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_11_38_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m113.503037"},{"key":"e_1_2_11_39_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2760918"},{"key":"e_1_2_11_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes9040202"},{"key":"e_1_2_11_41_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1485"},{"key":"e_1_2_11_42_2","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x19500629"},{"key":"e_1_2_11_43_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v10.i23.3500"},{"key":"e_1_2_11_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2017.11.013"},{"key":"e_1_2_11_45_2","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x07005077"},{"key":"e_1_2_11_46_2","doi-asserted-by":"publisher","DOI":"10.1089\/acm.2004.10.1041"},{"key":"e_1_2_11_47_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.45538"},{"key":"e_1_2_11_48_2","doi-asserted-by":"publisher","DOI":"10.1142\/s0192415x20500512"},{"key":"e_1_2_11_49_2","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_202003_20704"},{"key":"e_1_2_11_50_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5713"},{"key":"e_1_2_11_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(03)13615-x"},{"key":"e_1_2_11_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2015.05.005"},{"key":"e_1_2_11_53_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24193505"},{"key":"e_1_2_11_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.10.006"},{"key":"e_1_2_11_55_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/985176"},{"key":"e_1_2_11_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.112932"},{"key":"e_1_2_11_57_2","article-title":"A network pharmacology study to uncover the multiple molecular mechanism of the Chinese patent medicine toujiequwen granules in the treatment of corona virus disease (COVID-19)","volume":"1","author":"Yang B.","year":"2020","journal-title":"Research Square"},{"key":"e_1_2_11_58_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2539-x"},{"key":"e_1_2_11_59_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.013276"},{"key":"e_1_2_11_60_2","doi-asserted-by":"crossref","unstructured":"ChenH.andDuQ. Potential Natural Compounds for Preventing SARS-CoV-2 (2019-nCoV) Infection 2020.","DOI":"10.20944\/preprints202001.0358.v3"},{"volume-title":"Clinical Evidence Does Not Support Corticosteroid Treatment for 2019-nCoV Lung Injury","year":"2020","author":"Clark D Russell J. E. M.","key":"e_1_2_11_61_2"},{"key":"e_1_2_11_62_2","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2016-0020"},{"key":"e_1_2_11_63_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020200280"},{"key":"e_1_2_11_64_2","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13209"},{"key":"e_1_2_11_65_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10522-007-9083-9"},{"key":"e_1_2_11_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.05015-11"},{"key":"e_1_2_11_67_2","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-6-135"},{"key":"e_1_2_11_68_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000050454.01978.3B"},{"key":"e_1_2_11_69_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01619-09"},{"key":"e_1_2_11_70_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6104054"},{"key":"e_1_2_11_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2015.11.034"},{"key":"e_1_2_11_72_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.164.10.2104013"},{"key":"e_1_2_11_73_2","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2012.661513"},{"key":"e_1_2_11_74_2","doi-asserted-by":"crossref","unstructured":"PengH. Role of quercetin on inhibiting TGF-beta1 and TNF-alpha in lung of rats with silicosis Proceedings of the International Conference on Material and Environmental Engineering (ICMAEE 2014) 2014 Jiujiang China Atlantis Press.","DOI":"10.2991\/icmaee-14.2014.11"},{"key":"e_1_2_11_75_2","first-page":"455","article-title":"The inhibitory effect of quercetin on IL-6 production by LPS-stimulated neutrophils","volume":"2","author":"Liu J.","year":"2005","journal-title":"Cellular & Molecular Immunology"},{"key":"e_1_2_11_76_2","article-title":"Neuroprotective effects of ferulic acid against glutamate-induced neurotoxicity in pc12 cells","volume":"6","author":"Yi D.","year":"2008","journal-title":"Nutrients"},{"key":"e_1_2_11_77_2","unstructured":"JihongB. The effects of quercetin on serum IL-18 and IL-10 of nonalcoholic fatty liver disease in rats 2013 no. 1."},{"key":"e_1_2_11_78_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-014-8534-z"},{"key":"e_1_2_11_79_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011481"},{"key":"e_1_2_11_80_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi200303r"},{"key":"e_1_2_11_81_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.10.005"},{"key":"e_1_2_11_82_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1408.006"},{"key":"e_1_2_11_83_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2005.04.004"},{"key":"e_1_2_11_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-2600(20)30076-x"},{"key":"e_1_2_11_85_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00607-2020"},{"key":"e_1_2_11_86_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci60331"},{"key":"e_1_2_11_87_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0069-0"},{"key":"e_1_2_11_88_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904073106"},{"key":"e_1_2_11_89_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2432416"},{"key":"e_1_2_11_90_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2015.4546"},{"key":"e_1_2_11_91_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00271-13"},{"key":"e_1_2_11_92_2","first-page":"249","article-title":"Activity of Ginkgo biloba extract and quercetin on thrombomodulin expression and tissue-type plasminogen activator secretion by human umbilical vein endothelial cells","volume":"19","author":"Lan W. J.","year":"2006","journal-title":"Biomedical and Environmental Sciences \u2009:\u2009BES"},{"key":"e_1_2_11_93_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22760"},{"key":"e_1_2_11_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105046"},{"key":"e_1_2_11_95_2","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-6-13"},{"key":"e_1_2_11_96_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01288"},{"key":"e_1_2_11_97_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.12.011"},{"key":"e_1_2_11_98_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1021"},{"key":"e_1_2_11_99_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01185"},{"key":"e_1_2_11_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50064-9"},{"key":"e_1_2_11_101_2","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10698"},{"key":"e_1_2_11_102_2","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000004389"},{"key":"e_1_2_11_103_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5801591"},{"key":"e_1_2_11_104_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep24944"},{"key":"e_1_2_11_105_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt270"},{"key":"e_1_2_11_106_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18325-7"},{"key":"e_1_2_11_107_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-020-02524-5"},{"key":"e_1_2_11_108_2","article-title":"UniProt: the universal protein knowledge base","volume":"46","author":"UniProt Consortium T.","year":"2018","journal-title":"Nucleic Acid"},{"key":"e_1_2_11_109_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-019-1758-4"},{"key":"e_1_2_11_110_2","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.ra118.000713"},{"key":"e_1_2_11_111_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp101"},{"key":"e_1_2_11_112_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz163"},{"key":"e_1_2_11_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2017.03.016"},{"key":"e_1_2_11_114_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"e_1_2_11_115_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep34328"},{"key":"e_1_2_11_116_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep28089"},{"key":"e_1_2_11_117_2","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"e_1_2_11_118_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_2_11_119_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn892"},{"key":"e_1_2_11_120_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3951783"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2020\/8468303.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2020\/8468303.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2020\/8468303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T07:52:07Z","timestamp":1723017127000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2020\/8468303"}},"subtitle":[],"editor":[{"given":"Mario","family":"Ledda","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":120,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1155\/2020\/8468303"],"URL":"https:\/\/doi.org\/10.1155\/2020\/8468303","archive":["Portico"],"relation":{},"ISSN":["1741-427X","1741-4288"],"issn-type":[{"type":"print","value":"1741-427X"},{"type":"electronic","value":"1741-4288"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"2020-03-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8468303"}}