{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T03:38:29Z","timestamp":1764905909160,"version":"3.37.3"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T00:00:00Z","timestamp":1583712000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572182","SZSM201911002"],"award-info":[{"award-number":["81572182","SZSM201911002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"publisher","award":["81572182","SZSM201911002"],"award-info":[{"award-number":["81572182","SZSM201911002"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2020,3,9]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. The study aimed at investigating the effect of local infiltration analgesia (LIA) with ropivacaine on postoperative analgesia for patients undergoing ankle fracture surgery. <jats:italic>Methods<\/jats:italic>. Consecutive patients were retrospectively included and analysed according to their medical records from July 2014 to August 2018 in a tertiary hospital. Inclusion criteria were patients undergoing open reduction and internal fixation (ORIF) for ankle fractures under general anaesthesia. Moreover, patients should have received intravenous patient-controlled analgesia (iPCA) or LIA\u2009+\u2009iPCA for postoperative pain relief. The primary outcome indicator was visual analogue scale (VAS) from 8 hours to 48 hours after surgery. Secondary outcomes included postoperative opioid requirement, need for rescue medication, opioid-related adverse effects, and wound complications. <jats:italic>Results<\/jats:italic>. In total, 89 consecutive patients were included in the study. There were 48 males and 41 females. The average age was 44.6\u2009\u00b1\u20097.0 years, and VAS scores were significantly lower in the LIA\u2009+\u2009iPCA group at 8\u2009hours after surgery (1.51\u2009\u00b1\u20090.58\u2009cm vs 4.77\u2009\u00b1\u20091.83\u2009cm, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>). The time to first tramadol consumption was longer (580\u2009\u00b1\u200960.9 minutes vs 281\u2009\u00b1\u200986.4 minutes, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>), and the number of patients who need tramadol was lower in the LIA\u2009+\u2009iPCA group (18 vs 26, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.04<\/mml:mn><\/mml:mrow><\/mml:math>). There was a statistically significant reduction in morphine consumption (25.1\u2009\u00b1\u20096.3\u2009mg vs 73.4\u2009\u00b1\u20098.2\u2009mg, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:mrow><\/mml:math>) and opioid-related side effects in the LIA\u2009+\u2009iPCA group (4 vs 10, <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>p<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.023<\/mml:mn><\/mml:mrow><\/mml:math>). No major wound complications were noted in either group. However, there were 2 cases with superficial wound necrosis in group LIA\u2009+\u2009iPCA and 3 patients with superficial wound necrosis in group iPCA, and all cured by local wound care. <jats:italic>Conclusions<\/jats:italic>. The retrospective cohort study indicates that LIA with ropivacaine can provide better early postoperative pain management with a reduction of VAS scores for ankle fracture surgery. Patients receiving wound infiltration also experience decreased opioid consumption, a lower rate of analgesia-related side effects, and comparable wound complication rate.<\/jats:p>","DOI":"10.1155\/2020\/8542849","type":"journal-article","created":{"date-parts":[[2020,3,9]],"date-time":"2020-03-09T23:31:54Z","timestamp":1583796714000},"page":"1-7","source":"Crossref","is-referenced-by-count":7,"title":["Local Infiltration Analgesia with Ropivacaine Improves Postoperative Pain Control in Ankle Fracture Patients: A Retrospective Cohort Study"],"prefix":"10.1155","volume":"2020","author":[{"given":"Bao-Liang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Orthopaedic, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xizhe","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic, Binzhou People\u2019s Hospital, Binzhou 256600, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic, Binzhou People\u2019s Hospital, Binzhou 256600, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic, Binzhou People\u2019s Hospital, Binzhou 256600, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingshan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic, Binzhou People\u2019s Hospital, Binzhou 256600, Shandong Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7752-6217","authenticated-orcid":true,"given":"Hai-Qiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Integrative Medicine, Shaanxi University of Chinese Medicine, Xi\u2019an 712046, Shaanxi Province, 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